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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) CA3 (i)01113p-CA1_0111-Sub_001 Trilaminar S131502:Collateral-related:RO-targeting:CA3 Name derivation This is the CA3 variant of the canonical Somogyi CA1 trilaminar cell, and is the only name in the cited literature. CA3 clarifies the subregion of origin, since the name is otherwise generic. Synonym(s) CA3 horizontal trilaminar cell CA3 TL cell CA3 trilaminar cell CA3 trilaminar interneuron List of articles Click here to view the list Freund TF  (1996) Hippocampus Interneurons of the hippocampus. Freund TF, Buzsaki G. Hippocampus, 1996, 6 (4), Pages: 347 - 470 PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I Tags: morphology, connectivity, synapse probabilities Gloveli T  (2005) J Physiol Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro. Gloveli T, Dugladze T, Saha S, Monyer H, Heinemann U, Traub RD, Whittington MA, Buhl EH. J Physiol, 2005 Jan 1, 562 (Pt 1), Pages: 131 - 147 PMID: 15486016; DOI: 10.1113/jphysiol.2004.073007 Tags: membrane biophysics, connectivity, firing patterns, synapse probabilities Gloveli T  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book Neuronal Activity Patterns During Hippocampal Network Oscillations In Vitro Gloveli T, Kopell N, Dugladze T. Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 247 - 276 ISBN: 9781441909954 Tags: morphology, connectivity, synapse probabilities Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book Morphology of Hippocampal Neurons Vida I. Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68 ISBN: 9781441909954 Tags: morphology, connectivity, synapse probabilities

Morphology

Soma
	CA3:SO

Axons
	CA3:SR
	CA3:SL
	CA3:SP
	CA3:SO
	CA1:SR
	CA1:SP
	CA1:SO
	SUB:PL

Dendrites
	CA3:SO

Representative figure

Neuronal Activity Patterns During Hippocampal Network Oscillations In Vitro Gloveli T, Kopell N, Dugladze T Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, pages: 247 - 276 ISBN: 9781441909954;

"Fig. 3 Morphological and firing properties of [CA1] hippocampal neurons during pharmacologically induced gamma oscillations. Reconstructions of representative biocytin-filled pyramidal {CA1 Superficial Pyramidal} {CA1 Deep Pyramidal} (Ai), PV[parvalbumin]-positive basket (Bi) {CA1 Basket}, and trilaminar (Ci) cells {CA3 Trilaminar}. The soma and dendrites are drawn in red, whereas the axons are in black. CA3, CA3 area; str or., stratum oriens; str. pyr., stratum pyramidale; str. rad, stratum radiatum; str. l.-m., stratum lacunosum-moleculare. ... Panel Aii-C, adapted from Gloveli et al. (2005a); D, adapted from Hajos et al. (2004) "

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): -61.2±13.0 mV (8); 1 source
	Input resistance (Rin): 167.3±59.1 MΩ (8); 1 source
	Time constant (τm): 16.9±8.8 ms (8); 1 source
	Threshold potential (Vthresh): 12 mV (1); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 30 mV (1); 1 source
	Action potential amplitude (APampl): [69.0, 99.0] mV (2); 1 source
	Action potential width (APwidth): 0.57 ms (8); 1 source
	Max firing rate (Max F.R.): 101.5±62.2 Hz (8); 1 source
	Slow afterhyperpolarizing potential amplitude (Slow AHP): 0.1 mV (1); 1 source
	Sag ratio: 0.88 (1); 1 source

Notes

Merger with CA3 IS 01113 rejected because of the presence of axons in CA1 and Sub for these neurons.

Firing Pattern

Images

Parameters		View page
	PSTUT	[Evidence] [Firing Pattern]

Izhikevich Model

Parameters	Single Compartment	Downloads	Simulate
	subtype: 1 k=0.93;a= 0;b= -18.76;d= 74;C= 251;Vr= -63.13;Vt= -55.64;Vpeak= 17.01;Vmin= -52.62;	[FitFiles][CSV][XPP][Ensemble]	Simulate

Images

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory DG HIPROM CA3 Pyramidal CA3 Athorny Pyramidal* CA3c Pyramidal CA3c Umbrella Pyramidal* CA3 Bistratified CA3 Ivy CA3 Lucidum ORAX CA3 O-LM CA3 Interneuron Specific Oriens CA3 Interneuron Specific Quad CA3 SO-SO CA3 Trilaminar CA2 Pyramidal CA1 Back-Projection

Potential sources known to be avoided Excitatory or Inhibitory none known

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory CA3 Pyramidal CA3 Athorny Pyramidal* CA3c Pyramidal CA3c Umbrella Pyramidal* CA3 Giant CA3 Granule CA3 Axo-axonic CA3 Horizontal Axo-axonic CA3 Basket CA3 Basket CCK+ CA3 Horizontal Basket CCK+* CA3 Mossy Fiber-Associated Basket CCK+* CA3 Bistratified CA3 Ivy CA3 Bilayer Ivy* CA3 LMR-Targeting CA3 Lucidum* CA3 Lucidum LAX CA3 Lucidum ORAX CA3 Lucidum-Radiatum CA3 Spiny Lucidum CA3 Mossy Fiber-Associated CA3 Mossy Fiber-Associated ORDEN CA3 O-LM CA3 Recurrent O-LM* CA3 Interneuron Specific Oriens CA3 Perforant Path-Associated* CA3 Perforant Path-Associated Projecting* CA3 Interneuron Specific Quad CA3 QuadD-LM CA3 Radiatum CA3 R-LM CA3 SO-SO CA3 Trilaminar CA2 Wide-Arbor Basket CA1 Pyramidal CA1 Deep Pyramidal CA1 Superficial Pyramidal CA1 Radiatum Giant CA1 Axo-axonic CA1 Horizontal Axo-axonic CA1 Back-Projection CA1 Basket CA1 Horizontal Basket CA1 R-P Basket* CA1 Trilayer Basket* CA1 Vertical Basket* CA1 Basket CCK+ CA1 Horizontal Basket CCK+* CA1 Trilayer Basket CCK+* CA1 Bistratified CA1 RO-receiving CA3-targeting* CA1 Hippocampo-subicular Projecting ENK+ CA1 Ivy CA1 Interneuron Specific LMO-O CA1 LMR CA1 LMR-LM* CA1 Interneuron Specific LMR-O* CA1 LMR-R* CA1 Interneuron Specific LMR-R CA1 LMR Projecting CA1 O-LM CA1 Recurrent O-LM CA1 O-LMR CA1 Recurrent O-LMR* CA1 Interneuron Specific O-R CA1 O-RP* CA1 Interneuron Specific O-Targeting QuadD CA1 Oriens/Alveus CA1 Oriens-Bistratified CA1 Oriens-QuadA Projecting CA1 OR-LM CA1 O-RPO* CA1 Perforant Path-Associated CA1 Perforant Path-Associated QuadD CA1 QuadD-RP* CA1 Quadrilaminar CA1 Interneuron Specific R-O CA1 R-Receiving Apical-Targeting CA1 R-RO* CA1 R-RP* CA1 Radiatum CA1 Interneuron Specific RO-O CA1 Interneuron Specific RO-R* CA1 RO-RP* CA1 RP-RPO* CA1 Schaffer Collateral-Associated CA1 Schaffer Collateral-Correlated* CA1 Schaffer Collateral-Receiving R-Targeting CA1 SO-SO CA1 SO-SO Projecting* CA1 Trilaminar CA1 Radial Trilaminar Sub Wide-arbor Polymorphic* Sub Recurrent Polymorphic-Moleculare*

Potential targets known to be avoided Excitatory or Inhibitory none known

Oscillation Phase Locking

Category

Value