CA3 O-LM
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (i)11003 O-LM S121402:O-LM Family:O-LM-like:CA3

Name derivation
This is the canonical CA3 variant of the canonical CA1 O-LM cell. This is the only name in the cited literature. O-LM stands for "Oriens (dendrites) - Lacunosum-Moleculare (axons)."

Synonym(s)
CA3 O-LM cell
CA3 O-LM interneuron
CA3 O-LM interneurone

List of articles
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Gloveli T  (2005) J Physiol
Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro.
Gloveli T, Dugladze T, Saha S, Monyer H, Heinemann U, Traub RD, Whittington MA, Buhl EH.
J Physiol, 2005 Jan 1, 562 (Pt 1), Pages: 131 - 147
PMID: 15486016; DOI: 10.1113/jphysiol.2004.073007
Tags: morphology, membrane biophysics, connectivity, firing patterns, synapse probabilities
Gloveli T  (2005) Proc Natl Acad Sci U S A
Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus.
Gloveli T, Dugladze T, Rotstein HG, Traub RD, Monyer H, Heinemann U, Whittington MA, Kopell NJ.
Proc Natl Acad Sci U S A, 2005 Sep 13, 102 (37), Pages: 13295 - 13300
PMID: 16141320; DOI: 10.1073/pnas.0506259102
Tags: morphology
Gloveli T  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Neuronal Activity Patterns During Hippocampal Network Oscillations In Vitro
Gloveli T, Kopell N, Dugladze T.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 247 - 276
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities
Hajos N  (2013) J Neurosci
Input-output features of anatomically identified CA3 neurons during hippocampal sharp wave/ripple oscillation in vitro.
Hajos N, Karlocai MR, Nemeth B, Ulbert I, Monyer H, Szabo G, Erdelyi F, Freund TF, Gulyas AI.
J Neurosci, 2013 Jul, 33 (28), Pages: 11677 - 11691
PMID: 23843535; DOI: 10.1523/JNEUROSCI.5729-12.2013
Tags: synapse probabilities
Tort AB  (2007) Proc Natl Acad Sci U S A
On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus.
Tort AB, Rotstein HG, Dugladze T, Gloveli T, Kopell NJ.
Proc Natl Acad Sci U S A, 2007 Aug 14, 104 (33), Pages: 13490 - 13495
PMID: 17679692; DOI: 10.1073/pnas.0705708104
Tags: morphology

Supplemental PMIDs
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Morphology
Soma
CA3:SO
Axons
CA3:SLM
CA3:SR
CA3:SO
Dendrites
CA3:SO

Representative figure
On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus.
Tort AB, Rotstein HG, Dugladze T, Gloveli T, Kopell NJ
Proc Natl Acad Sci U S A, 2007 Aug 14, 104 (33), pages: 13490 - 13495
PMID: 17679692; DOI: 10.1073/pnas.0705708104


"Fig. 1. O-LM [oriens-lacunosum moleculare] cells {CA3 O-LM} posses higher axonal projections in the longitudinal direction of the CA3 area. Neurolucida reconstructed biocytin-filled O-LM cell in area CA3 from transverse (Left) and longitudinal slices (Right). The soma and dendrites are drawn in red, whereas the axon is in green. The horizontal dendritic branches were restricted to the stratum oriens. The axons crossed the pyramidal cell layer and extensively innervated the stratum lacunosum-moleculare of the area CA3. Note the much longer axonal ramification pattern in stratum lacunosum-moleculare of the longitudinal slice than of the transverse slice. Hippocampal layers are depicted schematically. CA3, CA3 area; str. or., stratum oriens; str. pyr., stratum pyramidale; str. rad., stratum radiatum; str. l.-m., stratum lacunosum-moleculare."


Molecular markers
Positive
None known
Negative
GABAa\alpha 6 (inference)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Input resistance (Rin): 315.1±161.1 MΩ (15); 1 source
Threshold potential (Vthresh): [16.0, 37.0] mV (2); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 34.8 mV (1); 1 source
Action potential amplitude (APampl): 109 mV (1); 1 source
Action potential width (APwidth): 0.84±0.2 ms (15); 1 source
Max firing rate (Max F.R.): 182±161.1 Hz (15); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 1.3 mV (1); 1 source
Sag ratio: 0.79±0.1 (10); 1 source


Firing Pattern
Images
Image Missing
Parameters View page
ASP. [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.51;a= 0.01;b= 2.39;d= 6;C= 65;Vr= -60.04;Vt= -30.87;Vpeak= 19.77;Vmin= -52.81; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID
138421 16141320
142104 23678009
151282 24204609
139421 21832203
168314 24978936

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG HIPROM
CA3 Pyramidal
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Bistratified
CA3 Ivy
CA3 Lucidum ORAX
CA3 O-LM
CA3 Interneuron Specific Oriens
CA3 Interneuron Specific Quad
CA3 SO-SO
CA3 Trilaminar
CA2 Pyramidal
CA1 Back-Projection

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
CA3 Pyramidal

Potential targets
Excitatory or Inhibitory
CA3 Athorny Pyramidal*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Giant
CA3 Granule
CA3 Axo-axonic
CA3 Horizontal Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Horizontal Basket CCK+*
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 LMR-Targeting
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 O-LM
CA3 Recurrent O-LM*
CA3 Interneuron Specific Oriens
CA3 Perforant Path-Associated*
CA3 Perforant Path-Associated Projecting*
CA3 Interneuron Specific Quad
CA3 QuadD-LM
CA3 Radiatum
CA3 R-LM
CA3 SO-SO
CA3 Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value