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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) CA3 (i)33200 LMR-Targeting S101302:Ivy/Neurogliaform Family:Ivy/Neurogliaform:CA3 Name derivation This name is simple, borrows from the cited names, and describes the axons that invade SLM and SR. CA3 distinguishes these cells from similar cells in other subregions. Synonym(s) CA3 L-M interneuron CA3 R cell CA3 R interneuron List of articles Click here to view the list Anderson WD  (2011) Pflugers Arch Properties and functional implications of I (h) in hippocampal area CA3 interneurons. Anderson WD, Galvan EJ, Mauna JC, Thiels E, Barrionuevo G. Pflugers Arch, 2011 Dec, 462 (6), Pages: 895 - 912 PMID: 21938402; DOI: 10.1007/s00424-011-1025-3 Tags: synapse probabilities Ascoli GA  (2009) J Comp Neurol Quantitative morphometry of electrophysiologically identified CA3b interneurons reveals robust local geometry and distinct cell classes. Ascoli GA, Brown KM, Calixto E, Card JP, Galvan EJ, Perez-Rosello T, Barrionuevo G. J Comp Neurol, 2009 Aug 20, 515 (6), Pages: 677 - 695 PMID: 19496174; DOI: 10.1002/cne.22082 Tags: morphology, membrane biophysics, firing patterns Supplemental PMIDs Click here to view the list of PMIDs 21938402 19496174

Morphology

Soma
	CA3:SLM

Axons
	CA3:SLM
	CA3:SR

Dendrites
	CA3:SLM
	CA3:SR
	CA3:SL

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)
	PV (multiple confirming inferences)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): -68±0.4 mV (56); 4 sources (92): [-72.17 , -68]
	Input resistance (Rin): 174±10 MΩ (56); 4 sources (92): [170.14 , 218]
	Time constant (τm): 21.2±1.17 ms (56); 2 sources (79): [21.2 , 24.7]
	Threshold potential (Vthresh): 22 mV (1); 4 sources (4): [22 , 27.5]
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 10.08±0.4 mV (56); 4 sources (92): [10.08 , 12.5]
	Action potential amplitude (APampl): 78±1.1 mV (56); 4 sources (92): [73.83 , 79]
	Action potential width (APwidth): 1±0.01 ms (56); 4 sources (92): [0.77 , 1]

Notes

This class is a merger of CA3 33200 L-M cells CA3 33200 R cells

Firing Pattern

Images

Parameters		View page
	D.RASP.NASP	[Evidence] [Firing Pattern]
	PSTUT	[Evidence] [Firing Pattern]

Izhikevich Model

Parameters	Single Compartment	Downloads	Simulate
	subtype: 1 k=1.1;a= 0.001;b= -61.26;d= 43;C= 54;Vr= -67.73;Vt= -24.09;Vpeak= 10.38;Vmin= -42.74;	[FitFiles][CSV][XPP][Ensemble]	Simulate

Images

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory DG Granule DG Adult-Born Immature Granule* DG Hilar Ectopic Granule DG Semilunar Granule DG HIPROM CA3 Pyramidal CA3c Pyramidal CA3c Umbrella Pyramidal* CA3 Granule CA3 Mossy Fiber-Associated Basket CCK+* CA3 Bistratified CA3 Ivy CA3 Bilayer Ivy* CA3 LMR-Targeting CA3 Lucidum* CA3 Lucidum LAX CA3 Lucidum ORAX CA3 Lucidum-Radiatum CA3 Spiny Lucidum CA3 Mossy Fiber-Associated CA3 Mossy Fiber-Associated ORDEN CA3 O-LM CA3 Recurrent O-LM* CA3 Interneuron Specific Oriens CA3 Perforant Path-Associated* CA3 Perforant Path-Associated Projecting* CA3 Interneuron Specific Quad CA3 QuadD-LM CA3 Radiatum CA3 R-LM CA3 Trilaminar CA2 Pyramidal CA1 Back-Projection MEC LII Stellate

Potential sources known to be avoided Excitatory or Inhibitory none known

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory CA3 Pyramidal CA3 Athorny Pyramidal* CA3c Pyramidal CA3c Umbrella Pyramidal* CA3 Giant CA3 Granule CA3 Axo-axonic CA3 Basket CA3 Basket CCK+ CA3 Mossy Fiber-Associated Basket CCK+* CA3 Bistratified CA3 Ivy CA3 LMR-Targeting CA3 Lucidum LAX CA3 Lucidum ORAX CA3 Lucidum-Radiatum CA3 Mossy Fiber-Associated CA3 Mossy Fiber-Associated ORDEN CA3 Perforant Path-Associated* CA3 Perforant Path-Associated Projecting* CA3 Interneuron Specific Quad CA3 QuadD-LM CA3 Radiatum CA3 R-LM

Potential targets known to be avoided Excitatory or Inhibitory none known

Oscillation Phase Locking

Category

Value