CA3 Granule
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (e)22100 Granule S010102:Glutamatergic GC:Granule:CA3

Name derivation
This is the only name in the cited literature. CA3 distinguishes these cells from the canonical DG granule cells.

Synonym(s)
CA3 granule cell

List of articles
Click here to view the list
Szabadics J  (2010) J Neurosci
Granule cells in the CA3 area.
Szabadics J, Varga C, Brunner J, Chen K, Soltesz I.
J Neurosci, 2010 Jun 16, 30 (24), Pages: 8296 - 8307
PMID: 20554881; DOI: 10.1523/JNEUROSCI.5602-09.2010
Tags: morphology, marker, membrane biophysics, connectivity, firing patterns, synapse probabilities

Supplemental PMIDs
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Morphology
Soma
CA3:SR
CA3:SL
Axons
CA3:SL
Dendrites
CA3:SLM
CA3:SR

Representative figure
Granule cells in the CA3 area.
Szabadics J, Varga C, Brunner J, Chen K, Soltesz I
J Neurosci, 2010 Jun 16, 30 (24), pages: 8296 - 8307
PMID: 20554881; DOI: 10.1523/JNEUROSCI.5602-09.2010


"Figure 2. Morphology and firing properties of CA3 GCs [granule cells] {CA3 Granule}. A, Whole-cell recorded, biocytin filled, and subsequently reconstructed CA3 GC [granule cell]. A1, Dendritic and axonal arborizations of a CA3 GC [granule cell] (DG [dentate gyrus], GC [granule cell] layer of the inner blade of the DG [dentate gyrus]; s.rad., stratum radiatum; s.luc., stratum lucidum; s.pyr., stratum pyramidale). The black dot in the inset indicates the location of the soma of the recorded cell within the hippocampus. Note the presence of large ("giant") terminals with filopodial extensions on the camera lucida reconstruction of the axonal arbor primarily restricted to the stratum lucidum; see also A2."


Molecular markers
Positive
CB
Prox1
Negative
CR (multiple confirming inferences)
GABAa\alpha 6 (inference)
Gaba-a-alpha (multiple confirming inferences)
NPY (inference)
PV (multiple confirming inferences)
VIP (inference)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): -78±0.5 mV (15); 1 source
Input resistance (Rin): 139±11 MΩ (15); 1 source
Time constant (τm): 17.1±1.8 ms (15); 1 source
Threshold potential (Vthresh): 27.4 mV (1); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 7.95 mV (1); 1 source
Action potential amplitude (APampl): 104.3 mV (1); 1 source
Action potential width (APwidth): [0.8, 1.1] ms (2); 1 source
Max firing rate (Max F.R.): >100 Hz (1); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 1.75 mV (1); 1 source
Sag ratio: 0.99 (1); 1 source

Notes
Occasional A:DG:SM.

Firing Pattern
Images
Image MissingImage Missing
Parameters View page
ASP. [Evidence] [Firing Pattern]
TSTUT.ASP. [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=2.25;a= 0.053;b= 1.54;d= 443;C= 241;Vr= -78.04;Vt= -64.88;Vpeak= -7.73;Vmin= -68.01; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
CA3 Ivy
CA3 Mossy Fiber-Associated

Potential sources
Excitatory or Inhibitory
DG HIPROM
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Bistratified
CA3 LMR-Targeting
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Spiny Lucidum
CA3 O-LM
CA3 Recurrent O-LM*
CA3 Perforant Path-Associated*
CA3 Perforant Path-Associated Projecting*
CA3 QuadD-LM
CA3 Radiatum
CA3 R-LM
CA3 Trilaminar
CA2 Pyramidal
CA1 Back-Projection
MEC LII Stellate

Potential sources known to be avoided
Excitatory or Inhibitory
CA3 Interneuron Specific Oriens
CA3 Interneuron Specific Quad

Targets of Output
Known targets
Excitatory or Inhibitory
CA3 Pyramidal
CA3 Ivy

Potential targets
Excitatory or Inhibitory
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Bilayer Ivy*
CA3 LMR-Targeting
CA3 Lucidum*
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Interneuron Specific Quad
CA3 QuadD-LM

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value