DG Interneuron Specific HIPRO*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)2201 Interneuron Specific HIPRO* S091201:Interneuron Specific:IS:DG

Name derivation
This is a new name derived from the interneuron specificity and is in the vein of HICAP, MOPP, and HIPP that stands for "HIlus PROjecting."

Synonym(s)
DG hilus-projecting cell

List of articles
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Wei YT  (2021) Journal of Comparative Neurology
Morpho-physiological properties and connectivity of vasoactive intestinal polypeptide-expressing interneurons in the mouse hippocampal dentate gyrus
Wei YT, Wu JW, Yeh CW, Shen HC, Wu KP, Vida I, Lien CC.
Journal of Comparative Neurology, 2021, 529 (10), Pages: 2658 - 2675
PMID: 33484471; DOI: 10.1002/cne.25116
Tags: morphology, marker, membrane biophysics

List of Hippocampome.org to NeuroMorpho.Org mappings
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  • Lien

    • Morphology
    Soma
    DG:SMi
    DG:SG
    DG:H
    Axons
    DG:H
    Dendrites
    DG:SMo
    DG:SMi

    Representative figure
    Morpho-physiological properties and connectivity of vasoactive intestinal polypeptide-expressing interneurons in the mouse hippocampal dentate gyrus
    Wei YT, Wu JW, Yeh CW, Shen HC, Wu KP, Vida I, Lien CC
    Journal of Comparative Neurology, 2021, 529 (10), pages: 2658 - 2675
    PMID: 33484471; DOI: 10.1002/cne.25116


    "FIGURE 3 Morpho-physiological classification of VIP+ INs. (a) Top, exemplar reconstructions of a hilus-projecting (HP) cell {DG Interneuron Specific HIPRO*} with axonal projections to the hilus; molecular layer-projecting (MP) cell with axonal distributions in the inner two-thirds of the molecular layer; bistratified (Bis) cell with axonal plexus distributed in the inner one-third of the molecular layer and hilus; trilamilar (Tri) cell with axonal arborization across the three layers. Somata and dendrites were in black. Axons of HP, MP, Bis and Tri cells were in red, blue, purple, and orange, respectively."


    Molecular markers
    Positive
    VIP
    Negative
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (multiple confirming inferences)
    PV (inference)
    vGluT3 (inference)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -47.5±2.2 mV (27); 1 source
    Input resistance (Rin): 889±73 MΩ (27); 1 source
    Threshold potential (Vthresh): 11.3±3.2 mV (27); 1 source
    Action potential amplitude (APampl): 71.6±2.3 mV (27); 1 source
    Action potential width (APwidth): 0.88±0.04 ms (27); 1 source
    Max firing rate (Max F.R.): 25.2±2.5 Hz (27); 1 source

    Notes

    DG (i)2201 Interneuron Specific Hilus-Projecting (IS HIPRO) cells [1103]

    Related types: DG (i)2203 HIMOLD (v2.0 on-hold unapproved)

    Notes: This type has no dendrites in DG:H, which distinguishes it from the 2203 neuron type. These cells are VIP+ and are speculated by the authors to be interneuron specific.

    VIP+. Ephys. FP. Lengths. NMO reconstructions.

    After review of DG (i)2201 IS HIPRO [#1103], I am in agreement with the evidence provided in the packet and approve of this neuron type for v2.0. - JDK 11/22/2021

    I approve. Only requested change, pre-pend IS to the formal name on page 1 of the packet. Also add tag indicating presence of reconstructions in NMO on page 1? - GAA 0125/2022

    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy
    DG Mossy MOLDEN
    DG AIPRIM
    DG Interneuron Specific COLTAR*
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA3c Pyramidal
    CA3 Spiny Lucidum
    CA3 Perforant Path-Associated Projecting*
    CA1 Local-Projecting Cajal-Retzius*
    CA1 LMR Projecting
    CA1 Neurogliaform Projecting
    CA1 Perforant Path-Associated
    EC LI-II Pyramidal-Fan
    MEC LII Stellate
    EC LII-III Pyramidal-Tripolar
    EC LIV-V Pyramidal-Horizontal
    MEC LV Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    DG Axo-axonic
    DG Axo-axonic GRALDEN*

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Basket
    DG Basket CCK+
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG HIPROM
    DG Ivy*
    DG MOLAX
    DG Outer Molecular Layer
    DG Total Molecular Layer
    CA3 Interneuron Specific Quad

    Potential targets known to be avoided
    Excitatory or Inhibitory
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Mossy
    DG Mossy MOLDEN

    Oscillation Phase Locking
    Category
    Value