DG Molecular Layer*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)3200 Molecular Layer* S100601:Ivy/Neurogliaform Family:MOPP-like:DG

Name derivation
This name best captures the essence of the authors' descriptions.

Synonym(s)
DG ML-like
DG molecular layer interneuron

List of articles
Click here to view the list
Hsu TT  (2016) Cerebral Cortex
Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways
Hsu TT, Lee CT, Tai MH, Lien CC.
Cerebral Cortex, 2016, 26 (6), Pages: 2715 - 2727
PMID: 26045570; DOI: 10.1093/cercor/bhv127
Tags: morphology
Szabo GG  (2017) Cell Reports
Extended Interneuronal Network of the Dentate Gyrus
Szabo GG, Du X, Oijala M, Varga C, Parent JM, Soltesz I.
Cell Reports, 2017, 20 (6), Pages: 1262 - 1268
PMID: 28793251; DOI: 10.1016/j.celrep.2017.07.042
Tags: morphology, marker, phases

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings

Morphology
Soma
DG:SMo
Axons
DG:SMo
Dendrites
DG:SMo
DG:SMi

Representative figure
Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways
Hsu TT, Lee CT, Tai MH, Lien CC
Cerebral Cortex, 2016, 26 (6), pages: 2715 - 2727
PMID: 26045570; DOI: 10.1093/cercor/bhv127


"Figure 3. Target cell-specific synaptic efficacy at COM- [hilar commissural pathway] and MPP-IN [medial perforant path-interneuron] synapses. ... (D-H) Comparison of light-evoked EPSCs between COM- and MPP-IN synapses. Top, exemplar reconstructions [H] {DG Molecular Layer*} of recorded INs. Dendrites, soma, and axons are shown in magenta, red, and black, respectively. The IML [inner molecular layer] (green zone) is outlined according to ChR2-eYFP expression of the same slice."


Molecular markers
Positive
CB1
Negative
CR (inference)
GABAa\alpha 6 (inference)
mGluR1a (inference)
PV (multiple confirming inferences)
SOM (multiple confirming inferences)
Mixed expression
None known

Electrophysiological properties
None known

Notes

DG (i)3200 Molecular Layer cells (MLC) [1078]

Related types: DG (i)3000 MOPP (v1.0 active)
DG (i)3300 VIP+ SM cell (v1.0 on-hold)
DG (i)3000 IS MOPP (v2.0 active unapproved)

Notes: This 3200 cell is proven to receive input from SMi, which is not proven for the 3000 cells. The axonal presence in SMi for this 3200 cell is well below the 15% threshold, which differentiates it from the 3300 cell.

This is a proposed merger between Hsu's ML-like neuron (v2.0 on-hold) and Szabo's molecular layer interneuron (new).

Hsu:

[Y:D:SMi{low}]
[N:A:SMi{low}]

synaptic contacts from COM and MPP stimulation.

Szabo:

[Y:D:DG:SMi]{low}
[N:D:DG:SG_H]{low}
[N:A:DG:SMi]{low}

CB1+

I have reviewed the evidence packet for this proposed v2.0 cell type and agree with the proposed merger between Hsuâ??s ML-like neuron and Szaboâ??s molecular layer interneuron. - JDK 10/13/2021

Approved. - GAA 01/19/2022

Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG Semilunar Granule
DG Cajal-Retzius*
DG Local-Projecting Cajal-Retzius*
DG Mossy
DG Mossy MOLDEN
DG AIPRIM
DG Interneuron Specific COLTAR*
DG COM-MOPP*
DG HICAP
DG Interneuron Specific IMOT*
DG HIPP
DG Recurrent HIPP*
DG HIPP-CAP*
DG Recurrent HIPP-CAP*
DG HIPROM
DG Ivy*
DG MOCAP
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG MOPP
DG Neurogliaform
DG Wide-Arbor Neurogliaform*
CA3c Pyramidal
CA3 Spiny Lucidum
CA3 Perforant Path-Associated Projecting*
CA1 Local-Projecting Cajal-Retzius*
CA1 LMR Projecting
CA1 Neurogliaform Projecting
CA1 Perforant Path-Associated
EC LI-II Pyramidal-Fan
MEC LII Stellate
EC LII-III Pyramidal-Tripolar
EC LIV-V Pyramidal-Horizontal
MEC LV Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
DG Granule
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Semilunar Granule
DG Cajal-Retzius*
DG Local-Projecting Cajal-Retzius*
DG Mossy MOLDEN
DG AIPRIM
DG Axo-axonic
DG Granulosum-targeting Axo-axonic*
DG Axo-axonic GRALDEN*
DG Basket
DG Basket GRALDEN*
DG Basket CCK+
DG Interneuron Specific COLTAR*
DG COM-MOPP*
DG HICAP
DG Interneuron Specific IMOT*
DG Interneuron Specific HIMOLD*
DG Interneuron Specific HIPRO*
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG MOPP
DG Neurogliaform
DG Wide-Arbor Neurogliaform*
CA1 Neurogliaform Projecting

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value