DG Cajal-Retzius*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (e)3000 Cajal-Retzius* S030301:Glutamatergic C-R:Cajal-Retzius:DG

Name derivation
This is the only name in the cited literature.

Synonym(s)
DG Cajal-Retzius cells

List of articles
Click here to view the list
Anstotz M  (2016) Cereb Cortex
"Developmental Profile, Morphology, and Synaptic Connectivity of Cajal-Retzius Cells in the Postnatal Mouse Hippocampus."
Anstotz M, Huang H, Marchionni I, Haumann I, Maccaferri G, Lubke JH.
Cereb Cortex, 2016 Feb, 26 (2), Pages: 855 - 72
PMID: 26582498; DOI: 10.1093/cercor/bhv271
Tags: morphology, marker, connectivity, synapse probabilities

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings

Morphology
Soma
DG:SMo
Axons
DG:SMo
Dendrites
DG:SMo

Representative figure
"Developmental Profile, Morphology, and Synaptic Connectivity of Cajal-Retzius Cells in the Postnatal Mouse Hippocampus."
Anstotz M, Huang H, Marchionni I, Haumann I, Maccaferri G, Lubke JH
Cereb Cortex, 2016 Feb, 26 (2), pages: 855 - 72
PMID: 26582498; DOI: 10.1093/cercor/bhv271


"Figure 8. NEUROLUCIDA reconstructions of biocytin-filled hippocampal CR [Cajal-Retzius] cells. [*]Representative examples[*] of reconstructed hippocampal CR cells filled with biocytin. Their somatodendritic configuration is given either in red or orange, and the axonal domain in blue or green to distinguish between the 2 neurons. The framed area shows the termination of an individual axonal collateral ending in a growth-cone like structures. The characteristic firing patterns of one of the reconstructed neurons is also shown in the corresponding color. (A1) Hippocampal CR cells with somata located in the SLM [stratum lacunosum-moleculare] and OML [outer molecular layer] <* 1050 *> with a local, nonprojecting axonal morphology."


Molecular markers
Positive
RLN
Negative
GABAa\alpha 6 (inference)
mGluR1a (inference)
SOM (multiple confirming inferences)
Mixed expression
None known

Electrophysiological properties
None known

Notes

DG (e)3000 Cajal-Retzius (C-R) neurons [1050]

Related types: DG (e)3000p-CA1_1000 Local-projecting Cajal-Retzius (approved v2.0 active)
CA1 (e)3000 Cajal-Retzius (v1.0 active)
CA1 (e)3000p-DG_1000 Local-projecting Cajal-Retzius (approved v2.0 active)

Notes:

animals are borderline too young (P6-P21)

FP present. reelin+. counts. A&D lengths. reconstructions in NMO.

"This particular cell was in a more dorsal section of the hippocampus leading to a stronger distortion comparing 3D layer outlines and 2D projection. The cell soma is close to the IML border (please note that we did not separate in OML, MML and IML). Although (rarely) CR cells can be located in the IML (including a small fraction of the dendrite), the major fraction of the dendrite is attracted by the fissure/Pia." - Anstötz 06/21/2018

Based on the quote from Anstötz, this type is now being interpreted as residing entirely within DG:SMo. - 06/28/2018

After reviewing the provided packet, I concur with the interpretations and approve of this neuron type for v2.0. - JDK 10/13/2021

Approved! I think this has reconstructions in NMO. Perhaps worth adding this bit of info on cover alongside markers and FP? This could easily be checked for all PMIDs using the "lit src" web link of NMO. - GAA 01/19/2022

Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG Cajal-Retzius*
DG Local-Projecting Cajal-Retzius*
DG COM-MOPP*
DG HIPP
DG Recurrent HIPP*
DG HIPP-CAP*
DG Recurrent HIPP-CAP*
DG HIPROM
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG MOPP
DG Neurogliaform
DG Wide-Arbor Neurogliaform*
CA3 Spiny Lucidum
CA3 Perforant Path-Associated Projecting*
CA1 Local-Projecting Cajal-Retzius*
CA1 LMR Projecting
CA1 Neurogliaform Projecting
CA1 Perforant Path-Associated
EC LI-II Pyramidal-Fan
MEC LII Stellate
EC LII-III Pyramidal-Tripolar
EC LIV-V Pyramidal-Horizontal
MEC LV Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
DG Granule
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Semilunar Granule
DG Cajal-Retzius*
DG Local-Projecting Cajal-Retzius*
DG Mossy MOLDEN
DG AIPRIM
DG Axo-axonic
DG Granulosum-targeting Axo-axonic*
DG Axo-axonic GRALDEN*
DG Basket
DG Basket GRALDEN*
DG Basket CCK+
DG Interneuron Specific COLTAR*
DG COM-MOPP*
DG HICAP
DG Interneuron Specific IMOT*
DG Interneuron Specific HIMOLD*
DG Interneuron Specific HIPRO*
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG MOPP
DG Neurogliaform
DG Wide-Arbor Neurogliaform*
CA1 Neurogliaform Projecting

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value