DG AIPRIM
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)2333 AIPRIM S131101:Collateral-related:SMi-H-targeting:DG

Name derivation
This is a new HC-derived name in the vein of HICAP, MOPP, and HIPP that stands for "Aspiny Interneuron with PRojections to the Inner Molecular layer."

Synonym(s)
DG aspiny interneuron with axonal projection to the inner molecular layer

List of articles
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Hosp JA  (2014) Hippocampus
Morpho-physiological criteria divide dentate gyrus interneurons into classes.
Hosp JA, Struber M, Yanagawa Y, Obata K, Vida I, Jonas P, Bartos M.
Hippocampus, 2014 Feb, 24 (2), Pages: 189 - 203
PMID: 24108530; DOI: 10.1002/hipo.22214
Tags: synapse probabilities
Lubke J  (1998) J Neurophysiol
Specialized electrophysiological properties of anatomically identified neurons in the hilar region of the rat fascia dentata.
Lubke J, Frotscher M, Spruston N.
J Neurophysiol, 1998 Mar, 79 (3), Pages: 1518 - 1534
PMID: 9497429
Tags: morphology, membrane biophysics, connectivity, firing patterns, synapse probabilities

Supplemental PMIDs
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List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings

Morphology
Soma
DG:H
Axons
DG:SMi
DG:SG
DG:H
Dendrites
DG:SMo
DG:SMi
DG:SG
DG:H

Representative figure
Specialized electrophysiological properties of anatomically identified neurons in the hilar region of the rat fascia dentata.
Lubke J, Frotscher M, Spruston N
J Neurophysiol, 1998 Mar, 79 (3), pages: 1518 - 1534
PMID: 9497429;


"FIG. 8. Camera lucida reconstructions of 2 [dentate] multipolar aspiny hilar interneurons {DG HIPROM} {DG AIPRIM}. ... Note that the axonal projection (red) terminates mainly within the inner molecular layer closer to the granule cell layer (cell in A) and the outer molecular layer (cell in B). Both cells have a prominent axonal domain in the hilus and in CA3c. H, hilar region; GL, granule cell layer;"


Molecular markers
Positive
None known
Negative
GABAa\alpha 6 (inference)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): -64±2 mV (4); 1 source
Input resistance (Rin): 363±62 MΩ (4); 1 source
Time constant (τm): 30±6 ms (4); 1 source
Threshold potential (Vthresh): 16 mV (1); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 12.3±2.3 mV (4); 1 source
Action potential amplitude (APampl): [76.0, 77.9] mV (2); 1 source
Action potential width (APwidth): 0.5±0.02 ms (4); 1 source
Max firing rate (Max F.R.): 81±9 Hz (4); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 9±2.7 mV (4); 1 source
Sag ratio: 0.8±0.04 (4); 1 source

Notes
N = 4. A:DG:SMo and A:CA3c are less than 15%. D:CA3c is less than 15%. Youngest rats may be adolescents. Aspiny. A:SG form basket-like boutons around GC somata. A:H form basket-like bouton arrays around somata. These cells are the inverse of DG (-)2232 basket cells. These have clear presence in SMi and H, and minimal in SG.

Firing Pattern
Images
Image Missing
Parameters View page
ASP.NASP [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.51;a= 0.002;b= 0.2;d= 6;C= 40;Vr= -63.39;Vt= -40.19;Vpeak= 7.37;Vmin= -53.34; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
DG Granule
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Semilunar Granule
DG Cajal-Retzius*
DG Local-Projecting Cajal-Retzius*
DG Mossy
DG Mossy MOLDEN
DG AIPRIM
DG Granulosum-targeting Axo-axonic*
DG Axo-axonic GRALDEN*
DG Basket
DG Basket GRALDEN*
DG Basket CCK+
DG Interneuron Specific COLTAR*
DG COM-MOPP*
DG HICAP
DG Interneuron Specific IMOT*
DG Hilus-Associated Interneuron*
DG Interneuron Specific HIMOLD*
DG HIPP
DG Recurrent HIPP*
DG HIPP-CAP*
DG Recurrent HIPP-CAP*
DG Interneuron Specific HIPRO*
DG HIPROM
DG Ivy*
DG MOCAP
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG MOPP
DG Neurogliaform
DG Wide-Arbor Neurogliaform*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Perforant Path-Associated Projecting*
CA3 Interneuron Specific Quad
CA2 Pyramidal
CA1 Local-Projecting Cajal-Retzius*
CA1 Back-Projection
CA1 LMR Projecting
CA1 Neurogliaform Projecting
CA1 Perforant Path-Associated
EC LI-II Pyramidal-Fan
MEC LII Stellate
EC LII-III Pyramidal-Tripolar
EC LIV-V Pyramidal-Horizontal
MEC LV Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
DG Axo-axonic

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
DG Granule
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Semilunar Granule
DG Mossy
DG Mossy MOLDEN
DG AIPRIM
DG Axo-axonic
DG Granulosum-targeting Axo-axonic*
DG Axo-axonic GRALDEN*
DG Basket
DG Basket GRALDEN*
DG Basket CCK+
DG COM-MOPP*
DG HICAP
DG Interneuron Specific IMOT*
DG Hilus-Associated Interneuron*
DG Interneuron Specific HIMOLD*
DG HIPP
DG Recurrent HIPP*
DG HIPP-CAP*
DG Recurrent HIPP-CAP*
DG Interneuron Specific HIPRO*
DG HIPROM
DG Ivy*
DG MOCAP
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG Wide-Arbor Neurogliaform*
CA3 Interneuron Specific Quad

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value