DG Outer Molecular Layer
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)3222 Outer Molecular Layer S100601:Ivy/Neurogliaform Family:MOPP-like:DG

Name derivation
This is the simplest of the names in the cited literature.

Synonym(s)
DG interneuron with outer molecular layer axons
DG OML cell

List of articles
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Mott DD  (1997) J Neurosci
Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity.
Mott DD, Turner DA, Okazaki MM, Lewis DV.
J Neurosci, 1997 Jun 1, 17 (11), Pages: 3990 - 4005
PMID: 9151716
Tags: morphology, membrane biophysics, synapse probabilities

Supplemental PMIDs
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List of Hippocampome.org to NeuroMorpho.Org mappings
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  • Turner

    • Morphology
    Soma
    DG:SG
    Axons
    DG:SMo
    Dendrites
    DG:SMo
    DG:SMi
    DG:SG
    DG:H

    Representative figure
    Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity.
    Mott DD, Turner DA, Okazaki MM, Lewis DV
    J Neurosci, 1997 Jun 1, 17 (11), pages: 3990 - 4005
    PMID: 9151716;


    "Figure 4. OML [outer molecular layer] cell {DG Outer Molecular Layer} reconstructions [in the dentate gyrus]. A, This [dentate] cell had an extensive axonal arbor most densely distributed in the OML and a fusiform soma at the D/H [dentate hilus border of zone 4] border from which the axon arose. The dendrites spanned from the OML of the upper blade to the OML of the beginning of the lower blade. B, The axonal arbor of this cell was more limited; nevertheless, it seemed clearly preferentially located in the OML. This cell also had dendrites reaching the OML and a less expansive dendritic tree with a vertically oriented fusiform soma."


    Molecular markers
    Positive
    None known
    Negative
    GABAa\alpha 6 (inference)
    mGluR1a (inference)
    SOM (multiple confirming inferences)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -57±2.6 mV (3); 1 source
    Input resistance (Rin): 252.3±78 MΩ (3); 1 source
    Time constant (τm): 16.9±1.8 ms (3); 1 source
    Max firing rate (Max F.R.): 13.5±7.3 Hz (3); 1 source

    Notes

    DG outer molecular layer (OML) 3222 cells

    DWW

    CLR 04/28/2011

    CW 04/29/2011

    Excellent! Also note that HIPP cells are spiny, OML are aspiny! - GAA

    DG (i)3222 Outer Molecular Layer (OML) cells [1006]

    After reviewing the provided [DG (i)3002 MOHIPP] packet, I concur with the interpretations and approve of this neuron type for v2.0. - JDK 10/13/2021

    I'm not convinced. I would probably consider writing off these [DG (i)3002 MOHIPP] cells as Outer Molecular Layer (3222) or MOLAX (3302) neurons?! Happy to re-discuss thoughâ?¦ - GAA 01/19/2022

    I think the OML interpretation has its merits, more so than the MOLAX interpretation. - DWW 01/21/2022

    I'd say I still favor the 3002 interpretation based on the low axonal and dendritic presence within SMi, but can also see interpreting the A-D pattern as MOLAX (3302) as the axonal and dendritic presence within SMi is around the ~15% threshold and there is a fair amount of branching. The OML interpretation I favor less than the MOLAX or MOHIPP interpretation as the dendritic presence within SG is far below the 15% threshold and there is minimal branching in the provided reconstruction. - JDK 01/21/2022

    Based on comparisons with the established v1.0 neuron types, I now posit that the blue MOHIPP cell [Fig. 4c from Lee et al., 2016] is a 3222 OML, and the brown MOHIPP cell [Fig. S2d from Lee et al., 2016] is a 3302 MOLAX. - DWW 01/22/2022

    I concur. - GAA 01/22/2022

    I am also in agreement. - JDK 01/22/2022

    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy
    DG Mossy MOLDEN
    DG AIPRIM
    DG Granulosum-targeting Axo-axonic*
    DG Basket
    DG Basket GRALDEN*
    DG Basket CCK+
    DG Interneuron Specific COLTAR*
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG Interneuron Specific HIPRO*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 Perforant Path-Associated Projecting*
    CA3 Interneuron Specific Quad
    CA2 Pyramidal
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Back-Projection
    CA1 LMR Projecting
    CA1 Neurogliaform Projecting
    CA1 Perforant Path-Associated
    EC LI-II Pyramidal-Fan
    MEC LII Stellate
    EC LII-III Pyramidal-Tripolar
    EC LIV-V Pyramidal-Horizontal
    MEC LV Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    DG Axo-axonic
    DG Axo-axonic GRALDEN*

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy MOLDEN
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Axo-axonic GRALDEN*
    DG Basket
    DG Basket GRALDEN*
    DG Basket CCK+
    DG Interneuron Specific COLTAR*
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Interneuron Specific HIMOLD*
    DG Interneuron Specific HIPRO*
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA1 Neurogliaform Projecting

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value