MEC LI-II Polar Interneuron*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
MEC (i)120000 LI-II Polar Interneuron* S152306:GABAergic:iLI-II:EC

Name derivation
This name is derived from a description of the way the axons and dendrites project from opposite sides of the soma.

Synonym(s)
MEC GABAergic neuron
MEC non-fast spiking GABAergic neuron

List of articles
Click here to view the list
Fuchs EC  (2016) Neuron
Local and distant input controlling excitation in layer II of the medial entorhinal cortex
Fuchs EC, Neitz A, Pinna R, Melzer S, Caputi A, Monyer H.
Neuron, 2016, 89 (1), Pages: 194 - 208
PMID: 26711115; DOI: 10.1016/j.neuron.2015.11.029
Tags: morphology
Melzer S  (2012) Science
Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex
Melzer S, Michael M, Caputi A, Eliava M, Fuchs EC, Whittington MA, Monyer H.
Science, 2012, 335 (6075), Pages: 1506 - 1510
PMID: 22442486; DOI: 10.1126/science.1217139
Tags: morphology


Morphology
Soma
EC:I
EC:II
Axons
EC:I
Dendrites
EC:II

Representative figure
Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex
Melzer S, Michael M, Caputi A, Eliava M, Fuchs EC, Whittington MA, Monyer H
Science, 2012, 335 (6075), pages: 1506 - 1510
PMID: 22442486; DOI: 10.1126/science.1217139


"Fig. 2. Hippocampal SOM+-projecting neurons form inhibitory synapses onto GABAergic neurons in the MEC. ... . (E) ... (Right) A representative reconstructed target cell {MEC LI-II Polar Interneuron*} (dendrites, black; axon, red). Scale bar, 100 [micro]m."


Molecular markers
Positive
None known
Negative
GABAa\alpha 6 (inference)
PV (multiple confirming inferences)
Mixed expression
None known

Electrophysiological properties
None known

Notes

MEC (i)120000 LI-II Polar interneurons (MEC LI-II PI) [6118]

Related types: EC (i)223111 LIII Bipolar (v2.0 on-hold unapproved)
EC (i)033333 LIII Bipolar (v2.0 on-hold unapproved)

Notes: This neuron type is restricted entirely to LI and LII, which distinguishes it from the other two Bipolar types.

FP.

After reviewing the provided packet, I am in agreement with the evidence provided and support the inclusion of the MEC (i) 120000 LI-II Bipolar Interneuron type as an active type for v2.0. - JDK 11/23/2021

I approve. But I don't like the name, because, when referring to cortical interneurons, bipolar typically indicates that two dendrites go in opposite directions, but not that the axons go one way and the dendrites the other. In this regard, see Petilla terminology (PING, NRN 2008) and subsequent analysis in NRN 2013. Not everyone has been systematic in heeding the recommendation, and the convention is different for sensory systems such as retina, but I find it unwise to stoke the confusion. We could name it polar, vertical, upward, or anything else you and JDK like. - GAA 02/02/2022

I would favor "polar." - DWW 02/04/2022

Polar is the best fit to me for x_MEC_(i)120000_LI-II_Bipolar_active_new. - JDK 02/04/2022

Firing Pattern
Images
No image is associated with this neuron
Parameters
No parameter associated with this neuron
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
none known

Potential sources
Excitatory or Inhibitory
CA2 Pyramidal
EC LI-II Multipolar-Pyramidal
EC LI-II Pyramidal-Fan
MEC LII Stellate
MEC LII-III Pyramidal-Multiform
EC LII-III Pyramidal-Tripolar
MEC LIII Complex Pyramidal
MEC LIII Bipolar Complex Pyramidal
MEC LV Pyramidal
MEC LV Superficial Pyramidal
MEC LII Basket
EC LII Basket-Neurogliaform
MEC LIII Multipolar Interneuron
MEC LIII Superficial Multipolar Interneuron
EC LII-III Superficial Polymorphic Interneuron*
MEC LIII Superficial Trilayered Interneuron

Potential sources known to be avoided
Excitatory or Inhibitory
LEC LIII Multipolar Principal
LEC LIII Complex Pyramidal
EC LII Axo-axonic

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
EC LI-II Multipolar-Pyramidal
EC LI-II Pyramidal-Fan
MEC LII Oblique Pyramidal
MEC LII Stellate
MEC LII-III Pyramidal-Multiform
EC LII-III Pyramidal-Tripolar
EC LIII Small Pyramidal
MEC LIII Complex Pyramidal
EC LIII Pyramidal
EC LIII Stellate
EC LIII-V Bipolar Pyramidal
EC LIV-V Pyramidal-Horizontal
MEC LV Principal*
MEC LV Pyramidal
EC LV Deep Pyramidal
MEC LV Superficial Pyramidal
EC LII Basket-Neurogliaform
EC LIII Bipolar Interneuron*
MEC LIII Superficial Multipolar Interneuron
MEC LI Neurogliaform*
EC LII-III Superficial Polymorphic Interneuron*
MEC LIII Superficial Trilayered Interneuron

Potential targets known to be avoided
Excitatory or Inhibitory
LEC LIII Complex Pyramidal

Oscillation Phase Locking
Category
Value