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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) MEC (i)333000 LIII Superficial Trilayered Interneuron S152006:GABAergic:iLIII:EC Name derivation All sources indicate medial localization of the morphology. "Superficial "distinguishes these cells from other trilayered cells. "trilayered" generically describes the multilayered axons and dendrites, since there is no clear cited name. Synonym(s) MEC layer III type 4 cell List of articles Click here to view the list Ferrante M  (2017) Cereb Cortex Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Cereb Cortex, 2017 Jun 1, 27 (6), Pages: 3186 - 3207 PMID: 27269961; DOI: 10.1093/cercor/bhw143 Tags: synapse probabilities Gloveli T  (1997) Neuroscience Morphological and electrophysiological characterization of layer III cells of the medial entorhinal cortex of the rat. Gloveli T, Schmitz D, Empson RM, Dugladze T, Heinemann U. Neuroscience, 1997 Apr, 77 (3), Pages: 629 - 648 PMID: 9070741; DOI: 10.1016/S0306-4522(96)00494-0 Tags: morphology, membrane biophysics, firing patterns Supplemental PMIDs Click here to view the list of PMIDs 18769556

Morphology

Soma
	EC:III

Axons
	EC:I
	EC:II
	EC:III

Dendrites
	EC:I
	EC:II
	EC:III

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): -62±5.9 mV (12); 1 source
	Input resistance (Rin): 36.8±11.4 MΩ (12); 1 source
	Time constant (τm): 12.7±4.8 ms (12); 1 source
	Threshold potential (Vthresh): 8 mV (1); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 11.2 mV (1); 1 source
	Action potential amplitude (APampl): 66.8±6.2 mV (12); 1 source
	Slow afterhyperpolarizing potential amplitude (Slow AHP): 1.1 mV (1); 1 source
	Sag ratio: 0.89 (1); 1 source

Notes

Failed unofficial merger proposals with EC 233000 MPI 1 III and EC 230000 MPI-BC II. Inhibitory because they have aspiny dendrites and fast time constant

Firing Pattern

Images

Parameters		View page
	ASP.NASP	[Evidence] [Firing Pattern]

Izhikevich Model

Parameters	Single Compartment	Downloads	Simulate
	subtype: 1 k=1.15;a= 0.004;b= 7.39;d= 1;C= 152;Vr= -59.18;Vt= -36.71;Vpeak= 17.73;Vmin= -54.96;	[FitFiles][CSV][XPP][Ensemble]	Simulate

Images

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory CA2 Pyramidal EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Oblique Pyramidal MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar MEC LIII Multipolar Principal EC LIII Small Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal MEC LV Multipolar-Pyramidal MEC LV Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform EC LIII Bipolar Interneuron* MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LI Neurogliaform* EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron MEC LIII Superficial Trilayered Interneuron

Potential sources known to be avoided Excitatory or Inhibitory LEC LIII Multipolar Principal LEC LIII Complex Pyramidal LEC LVI Multipolar-Pyramidal LEC LIII Multipolar Interneuron

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Oblique Pyramidal MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar MEC LIII Multipolar Principal EC LIII Small Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal EC LIV-V Pyramidal-Horizontal MEC LV Principal* MEC LV Pyramidal EC LV Deep Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform EC LIII Bipolar Interneuron* MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LI Neurogliaform* EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron MEC LIII Superficial Trilayered Interneuron

Potential targets known to be avoided Excitatory or Inhibitory LEC LIII Multipolar Principal LEC LIII Complex Pyramidal LEC LIII Multipolar Interneuron

Oscillation Phase Locking

Category

Value