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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) MEC (e)221100 LII Oblique Pyramidal S061706:Glutamatergic II:LI-II:EC Name derivation This names is derived from part of the cited description that is a mixture of two standard types. All sources indicate medial localization of the morphology. Synonym(s) MEC between oblique pyramidal and SC LII neuron MEC LII between oblique pyramidal and SC List of articles Click here to view the list Canto CB  (2012) Hippocampus Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex. Canto CB, Witter MP. Hippocampus, 2012 Jun, 22 (6), Pages: 1277 - 1299 PMID: 22161956; DOI: 10.1002/hipo.20993 Tags: morphology, membrane biophysics, firing patterns, synapse probabilities Ray S  (2014) Science Grid-layout and theta-modulation of layer 2 pyramidal neurons in medial entorhinal cortex. Ray S, Naumann R, Burgalossi A, Tang Q, Schmidt H, Brecht M. Science, 2014 Feb 21, 343 (6173), Pages: 891 - 896 PMID: 24457213; DOI: 10.1126/science.1243028 Tags: phases Tang Q  (2014) Neuron Pyramidal and stellate cell specificity of grid and border representations in layer 2 of medial entorhinal cortex. Tang Q, Burgalossi A, Ebbesen CL, Ray S, Naumann R, Schmidt H, Spicher D, Brecht M.. Neuron, 2014, Pages: 1191 - 1197 PMID: 25482025 Tags: phases

Morphology

Soma
	EC:II

Axons
	EC:III
	EC:IV

Dendrites
	EC:I
	EC:II

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): [-62.0, -59.0] mV (2); 1 source
	Input resistance (Rin): 400±98.0 MΩ (96); 1 source
	Time constant (τm): 15.8±14.7 ms (96); 1 source
	Threshold potential (Vthresh): [7.5, 8.4] mV (2); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): [7.1, 7.3] mV (2); 1 source
	Action potential amplitude (APampl): 69±19.6 mV (96); 1 source
	Action potential width (APwidth): 1.25±0.5 ms (96); 1 source
	Max firing rate (Max F.R.): >40 Hz (1); 1 source
	Slow afterhyperpolarizing potential amplitude (Slow AHP): [0.0, 6.0] mV (2); 1 source
	Sag ratio: 0.66 (96); 1 source

Notes

Failed unofficial merger proposals with MEC (+)331111p stellate II, EC (+)331000p excitatory II, and EC (+)231000 FOMP. A:V less than 15%. N = 5. Spiny dendrites.

Firing Pattern

Images

Parameters		View page
	ASP.NASP	[Evidence] [Firing Pattern]
	RASP.NASP	[Evidence] [Firing Pattern]

Izhikevich Model

Parameters	Single Compartment	Downloads	Simulate
	subtype: 1 k=0.62;a= 0.005;b= 11.69;d= 3;C= 118;Vr= -58.53;Vt= -43.52;Vpeak= 11.48;Vmin= -49.52;	[FitFiles][CSV][XPP][Ensemble]	Simulate
	subtype: 2 k=0.98;a= 0.004;b= -23.77;d= 119;C= 131;Vr= -62.65;Vt= -43.6;Vpeak= 7.85;Vmin= -52.68;	[FitFiles][CSV][XPP][Ensemble]	Simulate

Images

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory CA2 Pyramidal EC LI-II Multipolar-Pyramidal EC LI-II Pyramidal-Fan MEC LII Stellate MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal MEC LV Pyramidal MEC LV Superficial Pyramidal MEC LI-II Polar Interneuron* EC LII Axo-axonic MEC LII Basket EC LII Basket-Neurogliaform MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron MEC LI Neurogliaform* EC LII-III Superficial Polymorphic Interneuron* MEC LIII Superficial Trilayered Interneuron

Potential sources known to be avoided Excitatory or Inhibitory LEC LIII Multipolar Principal LEC LIII Complex Pyramidal

Targets of Output

Known targets Excitatory or Inhibitory none known

Potential targets Excitatory or Inhibitory MEC LII-III Pyramidal-Multiform EC LII-III Pyramidal-Tripolar MEC LIII Multipolar Principal EC LIII Small Pyramidal MEC LIII Complex Pyramidal MEC LIII Bipolar Complex Pyramidal EC LIII Pyramidal EC LIII Stellate EC LIII-V Bipolar Pyramidal EC LIV-V Pyramidal-Horizontal EC LIV-VI Deep Multipolar Principal MEC LV Multipolar-Pyramidal MEC LV Superficial Pyramidal EC LIII Bipolar Interneuron* MEC LIII Multipolar Interneuron MEC LIII Superficial Multipolar Interneuron EC LII-III Superficial Polymorphic Interneuron* EC LIII Pyramidal-Looking Interneuron MEC LIII Superficial Trilayered Interneuron

Potential targets known to be avoided Excitatory or Inhibitory LEC LIII Multipolar Principal LEC LIII Complex Pyramidal LEC LIII Multipolar Interneuron

Oscillation Phase Locking

Category	Value
Theta (deg):	166.81
Theta range:	[166.81, 175.31]
Theta measurements:	2
Theta representative selection:	rats, adult, unknown sex, juxtacellular, freely moving
In vivo firing rate (Hz):	2.10
Firing rate range:	[2.10, 2.10]
Firing rate measurements:	1
Firing rate representative selection:	rats, adult, unknown sex, juxtacellular, freely moving