Neuron type - CA1 RO-RP*

		* indicates new v2.0 neuron type
Name		Supertype (ID:Family:Type:Subregion)
	CA1 (i)0312 RO-RP*	S131504:Collateral-related:RO-targeting:CA1

Name derivation
	This name is a variant of "O-LM" since the dendrites are in SR and SO and the axons project to SR and SP. CA1 clarifies the subregion of origin, since the name is otherwise generic.

Synonym(s)

List of articles

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Bilash OM (2023) Cell Reports

Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit
Bilash OM, Chavlis S, Johnson CD, Poirazi P, Basu J.
Cell Reports, 2023, 42 (1), Pages: 111962 -
PMID: 36640337; DOI: 10.1016/j.celrep.2022.111962
Tags: morphology

Pouille F (2004) Nature

Routing of spike series by dynamic circuits in the hippocampus
Pouille F, Scanziani M.
Nature, 2004, 429 (6993), Pages: 717 - 723
PMID: 15170216; DOI: 10.1038/nature02615
Tags: morphology

Morphology

Soma
	CA1:SO

Axons
	CA1:SR
	CA1:SP

Dendrites
	CA1:SR
	CA1:SO

Representative figure

Routing of spike series by dynamic circuits in the hippocampus
Pouille F, Scanziani M
Nature, 2004, 429 (6993), pages: 717 - 723
PMID: 15170216; DOI: 10.1038/nature02615

"Figure 3 Onset-transient and late-persistent interneurons project to distinct layers. ... c, Camera lucida reconstruction of the neurons recorded in a (dark blue, dendrite; black, axon). Alv, alveus; or, stratum oriens; pyr, stratum pyramidale; rad, stratum radiatum; lm, stratum lacunosum moleculare; fis, fissure."

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	None known

Electrophysiological properties

None known

Notes

CA1 (i)0312 RO-RP neurons [4193]

                                        Related types:
                                

                                        CA1 (i)0333 Bistratified (v1.0 active)
                                

                                        CA1 (i)0333 Ivy (v1.0 active)
                                

                                        CA1 (i)0331 RP-RPO (v2.0 active)
                                

                                        CA1 (i)0302 SCR R-targeting (v1.0 active)
                                

Notes: The new cell from Bilash is being combined with a previously on-hold cell from Pouille. This neuron type clearly does not have A:SO, which distinguishes it from the other types.

N = 2

I am leaning toward yes because of the PCL rule, since there appears to be sufficient axons branching in SP. However, because the PCL rule states that we do not count the dendrites in SP, this should be 0312 not 0332. - DWW 05/12/2023

                                        I'm in agreement with you and lean towards yes. Given the PCL rule, we can discount the fact that the Pouille cell seemed to have the dendrites just passing through SP, whereas the Bilash cell has its dendrites clearly branching within SP. So 0312 I am in agreement with for both cells. - JDK 05/12/2023
                                

                                        approved - GAA 05/22/2023
                                

Firing Pattern

Images
	No image is associated with this neuron

Parameters
	No parameter associated with this neuron

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources

Excitatory or Inhibitory

none known

Potential sources

Excitatory or Inhibitory

	CA3 Pyramidal
	CA3c Pyramidal
	CA3c Umbrella Pyramidal*
	CA3 Trilaminar
	CA2 Pyramidal
	CA2 Bistratified
	CA1 Pyramidal
	CA1 Deep Pyramidal
	CA1 Superficial Pyramidal
	CA1 Radiatum Giant
	CA1 Back-Projection
	CA1 Bistratified
	CA1 Hippocampo-subicular Projecting ENK+
	CA1 Ivy
	CA1 Interneuron Specific LM-R
	CA1 Interneuron Specific LMO-O
	CA1 LMR
	CA1 Interneuron Specific LMR-O*
	CA1 LMR-R*
	CA1 Interneuron Specific LMR-R
	CA1 LMR Projecting
	CA1 Recurrent O-LM
	CA1 O-LMR
	CA1 Recurrent O-LMR*
	CA1 Interneuron Specific O-R
	CA1 O-RP*
	CA1 Interneuron Specific O-Targeting QuadD
	CA1 Oriens/Alveus
	CA1 Oriens-Bistratified
	CA1 Oriens-QuadA Projecting
	CA1 O-RPO*
	CA1 QuadD-RP*
	CA1 Quadrilaminar
	CA1 Interneuron Specific R-O
	CA1 R-Receiving Apical-Targeting
	CA1 R-RO*
	CA1 R-RP*
	CA1 Radiatum
	CA1 Interneuron Specific RO-O
	CA1 Interneuron Specific RO-R*
	CA1 RO-RP*
	CA1 RP-RPO*
	CA1 Schaffer Collateral-Associated
	CA1 Schaffer Collateral-Correlated*
	CA1 Schaffer Collateral-Receiving R-Targeting
	CA1 SO-SO
	CA1 SO-SO Projecting*
	CA1 Trilaminar
	CA1 Radial Trilaminar
	Sub CA1-Projecting Pyramidal
	EC LIII Small Pyramidal
	EC LIII Pyramidal

Potential sources known to be avoided

Excitatory or Inhibitory

none known

Targets of Output

Known targets

Excitatory or Inhibitory

none known

Potential targets

Excitatory or Inhibitory

	CA2 Wide-Arbor Basket
	CA1 Pyramidal
	CA1 Deep Pyramidal
	CA1 Superficial Pyramidal
	CA1 Radiatum Giant
	CA1 Axo-axonic
	CA1 Back-Projection
	CA1 Basket
	CA1 R-P Basket*
	CA1 Trilayer Basket*
	CA1 Vertical Basket*
	CA1 Basket CCK+
	CA1 Trilayer Basket CCK+*
	CA1 Bistratified
	CA1 RO-receiving CA3-targeting*
	CA1 Hippocampo-subicular Projecting ENK+
	CA1 Ivy
	CA1 LMR
	CA1 LMR-LM*
	CA1 Interneuron Specific LMR-O*
	CA1 LMR-R*
	CA1 Interneuron Specific LMR-R
	CA1 LMR Projecting
	CA1 Interneuron Specific O-Targeting QuadD
	CA1 Oriens/Alveus
	CA1 OR-LM
	CA1 Perforant Path-Associated
	CA1 Perforant Path-Associated QuadD
	CA1 QuadD-RP*
	CA1 Quadrilaminar
	CA1 Interneuron Specific R-O
	CA1 R-Receiving Apical-Targeting
	CA1 R-RO*
	CA1 R-RP*
	CA1 Radiatum
	CA1 Interneuron Specific RO-O
	CA1 Interneuron Specific RO-R*
	CA1 RO-RP*
	CA1 RP-RPO*
	CA1 Schaffer Collateral-Associated
	CA1 Schaffer Collateral-Correlated*
	CA1 Schaffer Collateral-Receiving R-Targeting
	CA1 Radial Trilaminar

Potential targets known to be avoided

Excitatory or Inhibitory

none known

Oscillation Phase Locking