CA2 Wide-Arbor Basket
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA2 (i)2232p-CA3_00030-CA1_0030 Wide-Arbor Basket S110703:Perisomatic-targeting:Basket:CA2

Name derivation
This name is derived from the cited name, but sounds better to the ear when the modfiers precede the core name. CA2 distinguishes these cells from basket cells in other subregions.

Synonym(s)
CA2 basket cell with wide arbor

List of articles
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Mercer A  (2007) J Neurosci
Characterization of neurons in the CA2 subfield of the adult rat hippocampus.
Mercer A, Trigg HL, Thomson AM.
J Neurosci, 2007 Jul 4, 27 (27), Pages: 7329 - 7338
PMID: 17611285; DOI: 10.1523/JNEUROSCI.1829-07.2007
Tags: morphology, marker, membrane biophysics, firing patterns, synapse probabilities
Mercer A  (2012) Hippocampus
Local circuitry involving parvalbumin-positive basket cells in the CA2 region of the hippocampus.
Mercer A, Eastlake K, Trigg HL, Thomson AM.
Hippocampus, 2012 Jan, 22 (1), Pages: 43 - 56
PMID: 20882544; DOI: 10.1002/hipo.20841
Tags: morphology

Supplemental PMIDs
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Morphology
Soma
CA2:SP
Axons
CA3:SP
CA2:SP
CA1:SP
Dendrites
CA3:SP
CA2:SLM
CA2:SR
CA2:SP
CA2:SO
CA1:SP

Representative figure
Local circuitry involving parvalbumin-positive basket cells in the CA2 region of the hippocampus.
Mercer A, Eastlake K, Trigg HL, Thomson AM
Hippocampus, 2012 Jan, 22 (1), pages: 43 - 56
PMID: 20882544; DOI: 10.1002/hipo.20841


"FIGURE 5. Examples of CA2 pyramid to wide dendritic arbor basket cell connections. In A1, the reconstruction of one of these cell pairs is shown (basket cell dendrites black, axon red, pyramidal cell dendrites green). The basket cell {CA2 Wide-Arbor Basket} was PV[parvalbumin]-immunopositive. A putative contact between the pyramidal cell and the basket cell is represented by a purple square. An image of the contact is shown in the bottom left panel."


Molecular markers
Positive
Gaba-a-alpha (inference)
PV
Negative
5HT-3 (inference)
CB (confirmed by inference)
CCK (multiple confirming inferences)
GABAa\alpha 6 (inference)
VIP (multiple confirming inferences)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): -74.9±5.6 mV (10); 1 source
Input resistance (Rin): 111.8±36.7 MΩ (10); 1 source
Time constant (τm): 12.6±4.2 ms (10); 1 source
Threshold potential (Vthresh): [26.0, 34.0] mV (2); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 19.5±9 mV (10); 1 source
Action potential amplitude (APampl): 65.5±7.1 mV (10); 1 source
Action potential width (APwidth): 0.6±0.1 ms (10); 1 source
Max firing rate (Max F.R.): >125 Hz (1); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 7 mV (1); 1 source
Sag ratio: 0.55 (1); 1 source

Notes
The cells from Mercer 2007, formerly 2332 basket cells, have been reinterpreted so proximal SO and SR are considered to be extensions of SP. Mercer (2007): distal portions of horizontal dendrites are sparsely spiny. Mercer (2012): dendrites putatively contact pyramidal somata or proximal dendrites. Borderline: D:CA3:SP and D:CA1:SP.

Firing Pattern
Images
Image Missing
Parameters View page
ASP.NASP [Evidence] [Firing Pattern]
RASP.NASP [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.51;a= 0.006;b= -2.16;d= 66;C= 148;Vr= -63.2;Vt= -32.84;Vpeak= 35.01;Vmin= -38.33; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
CA2 Pyramidal

Potential sources
Excitatory or Inhibitory
DG Granule
DG HIPROM
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Giant
CA3 Axo-axonic
CA3 Horizontal Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Horizontal Basket CCK+*
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Bilayer Ivy*
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Interneuron Specific Oriens
CA3 Perforant Path-Associated Projecting*
CA3 Interneuron Specific Quad
CA3 Trilaminar
CA2 Basket
CA2 Wide-Arbor Basket
CA2 Bistratified
CA2 SP-SR
CA1 Axo-axonic
CA1 Horizontal Axo-axonic
CA1 Back-Projection
CA1 Basket
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 RO-receiving CA3-targeting*
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 O-RP*
CA1 Oriens/Alveus
CA1 Oriens-QuadA Projecting
CA1 O-RPO*
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 R-RP*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Trilaminar
CA1 Radial Trilaminar
Sub CA1-Projecting Pyramidal
MEC LII Stellate
EC LIII Small Pyramidal
EC LIII Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
CA2 Pyramidal

Potential targets
Excitatory or Inhibitory
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Bilayer Ivy*
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Interneuron Specific Quad
CA3 QuadD-LM
CA2 Basket
CA2 Wide-Arbor Basket
CA2 Bistratified
CA1 Pyramidal
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Axo-axonic
CA1 Back-Projection
CA1 Basket
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 Ivy
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 RP-RPO*
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value