CA2 Bistratified
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA2 (i)0333p-CA1__0101 Bistratified S131503:Collateral-related:RO-targeting:CA2

Name derivation
The is the only name in the cited literature. This cell has the essence of the CA1 and CA3 bistratified cells in terms of marker expression.

Synonym(s)
CA2 bistratified cell

List of articles
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Mercer A  (2007) J Neurosci
Characterization of neurons in the CA2 subfield of the adult rat hippocampus.
Mercer A, Trigg HL, Thomson AM.
J Neurosci, 2007 Jul 4, 27 (27), Pages: 7329 - 7338
PMID: 17611285; DOI: 10.1523/JNEUROSCI.1829-07.2007
Tags: morphology, marker, membrane biophysics, firing patterns, synapse probabilities

Supplemental PMIDs
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Morphology
Soma
CA2:SP
Axons
CA2:SR
CA2:SP
CA2:SO
CA1:SR
CA1:SO
Dendrites
CA2:SR
CA2:SP
CA2:SO

Representative figure
Characterization of neurons in the CA2 subfield of the adult rat hippocampus.
Mercer A, Trigg HL, Thomson AM
J Neurosci, 2007 Jul 4, 27 (27), pages: 7329 - 7338
PMID: 17611285; DOI: 10.1523/JNEUROSCI.1829-07.2007


"Figure 4. Dendritic and axonal patterns of bistratified cells recorded and filled in the CA1 and CA2 regions... Ba, Reconstruction of a CA2 bistratified cell {CA2 Bistratified} using a drawing tube. This cell presented a narrow dendritic arbor (in black) that extended from SO to SR without entering SLM. The axon (in red) was strongly polarized and arborized mainly in SO and SR of CA2 and CA1 but did not enter CA3. The bistratified cell was CCK [cholecystokinin] immunonegative ... Ca,Reconstruction of another CA2 bistratified cell. This interneuron presented a broad dendritic arbor (in black) that extended to the CA1 and CA3 regions. The axonal arbor of this bistratified cell (in red) was strongly polarized ramifying in SO and SR of the CA2 and CA1 regions but not CA3."


Molecular markers
Positive
Gaba-a-alpha (inference)
PV
Negative
5HT-3 (inference)
CB (confirmed by inference)
CCK (confirmed by inference)
GABAa\alpha 6 (inference)
VIP (multiple confirming inferences)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Resting membrane potential (Vrest): -72.7±1.1 mV (3); 1 source
Input resistance (Rin): 83.3±16.7 MΩ (3); 1 source
Time constant (τm): 13.7±10 ms (3); 1 source
Threshold potential (Vthresh): [42.0, 56.0] mV (2); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 14.4±11.8 mV (3); 1 source
Action potential amplitude (APampl): 65.2±7.8 mV (3); 1 source
Action potential width (APwidth): 0.4±0.1 ms (3); 1 source
Slow afterhyperpolarizing potential amplitude (Slow AHP): 3.2 mV (1); 1 source
Sag ratio: 0.99 (1); 1 source


Firing Pattern
Images
Image Missing
Parameters View page
ASP. [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=0.8;a= 0.008;b= 4.75;d= 4;C= 118;Vr= -74.1;Vt= -40.19;Vpeak= 11.46;Vmin= -53.61; Simulate
Images
Image Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
CA2 Pyramidal

Potential sources
Excitatory or Inhibitory
DG Granule
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA2 Basket
CA2 Wide-Arbor Basket
CA2 Bistratified
CA2 SP-SR

Potential sources known to be avoided
Excitatory or Inhibitory
none known

Targets of Output
Known targets
Excitatory or Inhibitory
CA2 Pyramidal

Potential targets
Excitatory or Inhibitory
CA2 Basket
CA2 Wide-Arbor Basket
CA2 Bistratified
CA2 SP-SR
CA1 Pyramidal
CA1 Deep Pyramidal
CA1 Superficial Pyramidal
CA1 Radiatum Giant
CA1 Axo-axonic
CA1 Horizontal Axo-axonic
CA1 Back-Projection
CA1 Basket
CA1 Horizontal Basket
CA1 R-P Basket*
CA1 Trilayer Basket*
CA1 Vertical Basket*
CA1 Basket CCK+
CA1 Horizontal Basket CCK+*
CA1 Trilayer Basket CCK+*
CA1 Bistratified
CA1 RO-receiving CA3-targeting*
CA1 Hippocampo-subicular Projecting ENK+
CA1 Ivy
CA1 Interneuron Specific LMO-O
CA1 LMR
CA1 LMR-LM*
CA1 Interneuron Specific LMR-O*
CA1 LMR-R*
CA1 Interneuron Specific LMR-R
CA1 LMR Projecting
CA1 O-LM
CA1 Recurrent O-LM
CA1 O-LMR
CA1 Recurrent O-LMR*
CA1 Interneuron Specific O-R
CA1 O-RP*
CA1 Interneuron Specific O-Targeting QuadD
CA1 Oriens/Alveus
CA1 Oriens-Bistratified
CA1 Oriens-QuadA Projecting
CA1 OR-LM
CA1 O-RPO*
CA1 Perforant Path-Associated
CA1 Perforant Path-Associated QuadD
CA1 QuadD-RP*
CA1 Quadrilaminar
CA1 Interneuron Specific R-O
CA1 R-Receiving Apical-Targeting
CA1 R-RO*
CA1 R-RP*
CA1 Radiatum
CA1 Interneuron Specific RO-O
CA1 Interneuron Specific RO-R*
CA1 RO-RP*
CA1 RP-RPO*
CA1 Schaffer Collateral-Associated
CA1 Schaffer Collateral-Correlated*
CA1 Schaffer Collateral-Receiving R-Targeting
CA1 SO-SO
CA1 SO-SO Projecting*
CA1 Trilaminar
CA1 Radial Trilaminar

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value