CA3c Pyramidal
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3c (e)03223p-DG_0101-CA2_0101-CA1_0101-Sub_100 Pyramidal S040402:Glutamatergic PC:Pyramidal:CA3

Name derivation
The partition modifier distinguishes these cells from the canonical CA3 Pyramidal cells, because of the lack of SLM in CA3c. CA3 distinguishes these cells from pyramidal cells in other subregions.

Synonym(s)
CA3c pyramidal cell
CA3c pyramidal neuron
proximal CA3 pyramidal cell
pyramidal cell in the most proximal portion of CA3
pyramidal cell in the portion of CA3 most proximal to the DG
pyramidal cell located proximally in CA3

List of articles
Click here to view the list
Bernard C  (1994) Hippocampus
Model of local connectivity patterns in CA3 and CA1 areas of the hippocampus.
Bernard C, Wheal HV.
Hippocampus, 1994 Oct, 4 (5), Pages: 497 - 529
PMID: 7889123; DOI: 10.1002/hipo.450040502
Tags: morphology, connectivity, synapse probabilities
Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities
Hajos N  (2013) J Neurosci
Input-output features of anatomically identified CA3 neurons during hippocampal sharp wave/ripple oscillation in vitro.
Hajos N, Karlocai MR, Nemeth B, Ulbert I, Monyer H, Szabo G, Erdelyi F, Freund TF, Gulyas AI.
J Neurosci, 2013 Jul, 33 (28), Pages: 11677 - 11691
PMID: 23843535; DOI: 10.1523/JNEUROSCI.5729-12.2013
Tags: morphology, synapse probabilities
Ishizuka N  (1990) J Comp Neurol
Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat.
Ishizuka N, Weber J, Amaral DG.
J Comp Neurol, 1990 May 22, 295 (4), Pages: 580 - 623
PMID: 2358523; DOI: 10.1002/cne.902950407
Tags: morphology, synapse probabilities
Li XG  (1994) J Comp Neurol
The hippocampal CA3 network: an in vivo intracellular labeling study.
Li XG, Somogyi P, Ylinen A, Buzsaki G.
J Comp Neurol, 1994 Jan 8, 339 (2), Pages: 181 - 208
PMID: 8300905; DOI: 10.1002/cne.903390204
Tags: morphology, connectivity, synapse probabilities
Oliva A  (2016) Hippocampus
Spatial Coding and Physiological Properties of Hippocampal Neurons in the Cornu Ammonis Subregions
Oliva A, Fernandez-Ruiz A, Buzsaki G, Berenyi A.
Hippocampus, 2016, Pages: 1593 - 1607
PMID: 27650887
Tags: phases
Patton PE  (1995) Hippocampus
Connection matrix of the hippocampal formation: I. The dentate gyrus.
Patton PE, McNaughton B.
Hippocampus, 1995, 5 (4), Pages: 245 - 286
PMID: 8589792; DOI: 10.1002/hipo.450050402
Tags: morphology, connectivity, synapse probabilities
Sanchez-Aguilera A  (2021) PLoS Biology
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo
Sanchez-Aguilera A, Wheeler DW, Jurado-Parras T, Valero M, Nokia MS, Cid E, Fernandez-Lamo I, Sutton N, Garcia-Rincon D, de la Prida LM, Ascoli GA.
PLoS Biology, 2021, 19 (5), Pages: 1 - 28
PMID: 33956790; DOI: 10.1371/journal.pbio.3001213
Tags: phases
Scharfman HE  (2007) Prog Brain Res
The CA3 "backprojection" to the dentate gyrus.
Scharfman HE.
Prog Brain Res, 2007, 163, Pages: 627 - 637
PMID: 17765742; DOI: 10.1016/S0079-6123(07)63034-9
Tags: morphology, connectivity, synapse probabilities
Spruston N  (2007) The Hippocampus Book
Chapter 5: Structural and functional properties of hippocampal neurons
Spruston N, McBain C.
The Hippocampus Book, 2007, Pages: 133 - 200
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Turner DA  (1995) Journal of Comparative Neurology
Morphometric and electrical properties of reconstructed hippocampal CA3 neurons recorded in vivo
Turner DA, Li XG, Pyapali GK, Ylinen A, Buzsaki G..
Journal of Comparative Neurology, 1995, 356 (4), Pages: 580 - 594
PMID: 7560268; DOI: 10.1002/cne.903560408
Tags: synapse probabilities
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities
Winnubst J  (2019) Cell
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain
Winnubst J, Bas E, Ferreira TA, Wu Z, Economo MN, Edson P, Arthur BJ, Bruns C, Rokicki K, Schauder D, Olbris DJ, Murphy SD, Ackerman DG, Arshadi C, Baldwin P, Blake R, Elsayed A, Hasan M, Ramirez D, Dos Santos B, Weldon M, Zafar A, Dudman JT, Gerfen CR, Hantman AW, Korff W, Sternson SM, Spruston N, Svoboda K, Chandrashekar J..
Cell, 2019, 179 (1), Pages: 268 - 281
PMID: 31495573; DOI: 10.1016/j.cell.2019.07.042
Tags: synapse probabilities
Witter MP  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Connectivity of the Hippocampus
Witter MP.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 5 - 26
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities
Wittner L  (2007) Brain Structure and Function
Three-dimensional reconstruction of the axon arbor of a CA3 pyramidal cell recorded and filled in vivo
Wittner L, Henze DA, Zaborszky L, Buzsaki G.
Brain Structure and Function, 2007, 212 (1), Pages: 75 - 83
PMID: 17717699; DOI: 10.1007/s00429-007-0148-y
Tags: synapse probabilities

Supplemental PMIDs
Click here to view the list of PMIDs

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Claiborne
  • Orlowski
  • Turner

  • Morphology
    Soma
    CA3:SP
    Axons
    DG:SMi
    DG:H
    CA3:SR
    CA3:SO
    CA2:SR
    CA2:SO
    CA1:SR
    CA1:SO
    SUB:SM
    Dendrites
    CA3:SR
    CA3:SL
    CA3:SP
    CA3:SO

    Representative figure
    The hippocampal CA3 network: an in vivo intracellular labeling study.
    Li XG, Somogyi P, Ylinen A, Buzsaki G
    J Comp Neurol, 1994 Jan 8, 339 (2), pages: 181 - 208
    PMID: 8300905; DOI: 10.1002/cne.903390204


    "Fig. 14. Reconstruction of the dendrites (nine superimposed sections) and partial reconstruction of the axonal (three sections only) arborization of the two neighboring [CA3] pyramidal cells {CA3c Pyramidal} shown in Figures 13, 15, and 16 (R32). Processes shown in red can belong to either of the cells. Dendritic spines are not drawn. The main axon collaterals traced to one of the axon initial segments (green) and those traced to the other (blue) are shown separately. No attempt was made to follow axon collaterals once they reached the inner molecular layer. Note that both cells send axon collaterals to both blades of the dentate molecular layer. The terminal branches of the apical dendrites are artificially truncated at the granule cell body layer because in the two-dimensional superimposition of the sections they would have falsely appeared in the granule cell layer."


    Molecular markers
    Positive
    alpha-actinin-2
    BDNF
    Bok
    Caln
    CaM
    Disc1
    GABAa\alpha 4
    GABAa\alpha 5
    Man1a (weak positive)
    Math-2
    mGluR1
    mGluR5
    Mus1R
    Mus3R
    Mus4R
    Neuropilin2
    NG
    p-CREB
    SCIP
    vGlut1
    Negative
    5HT-3
    CB
    CGRP
    CR
    ENK
    ErbB4
    GABAa \delta
    GABAa\alpha 3
    GABAa\alpha 6 (confirmed by inference)
    GABAa\gamma 1
    GAT-3
    GAT-1
    Id-2
    mGluR1a (confirmed by inference)
    mGluR2
    mGluR2/3
    mGluR3
    Mus2R
    NPY
    PCP4
    PPTA
    Prox1
    PV
    RLN
    SOM (confirmed by inference)
    Sub P Rec
    vGAT
    VIP
    Mixed expression
    CB1 (unresolved)
    CCK (unresolved)
    GABAa\alpha 2 (subcellular expression differences)
    GABAa\beta 1 (subcellular expression differences)
    GABAa\beta 2 (subcellular expression differences)
    GABAa\beta 3 (subcellular expression differences)
    GABAa\gamma 2 (subcellular expression differences)
    Gaba-a-alpha (subcellular expression differences)
    mGluR5a (subcellular expression differences)
    nNOS (species/protocol differences)
    vGluT3 (species/protocol differences)

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -62±0.9 mV (32); 2 sources (53): [-62 , -55.1]
    Input resistance (Rin): 52±3.5 MΩ (41); 2 sources (62): [24.8 , 52]
    Time constant (τm): 16±1.2 ms (41); 2 sources (62): [12.2 , 16]
    Threshold potential (Vthresh): 15 mV (1); 1 source
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 3.5 mV (1); 1 source
    Action potential amplitude (APampl): 66±1.4 mV (42); 1 source
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 5.1±0.6 mV (31); 1 source


    Firing Pattern
    Images
    Image MissingImage MissingImage Missing
    Parameters View page
    TSWB.SLN [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=3.01;a= 0.002;b= 19.36;d= 104;C= 244;Vr= -62.29;Vt= -45.27;Vpeak= 17.43;Vmin= -47.37; Simulate
    Images
    Image Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    DG Granule
    CA3c Pyramidal
    CA3 Axo-axonic

    Potential sources
    Excitatory or Inhibitory
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG HIPROM
    CA3 Pyramidal
    CA3 Athorny Pyramidal*
    CA3c Umbrella Pyramidal*
    CA3 Giant
    CA3 Granule
    CA3 Horizontal Axo-axonic
    CA3 Basket
    CA3 Basket CCK+
    CA3 Horizontal Basket CCK+*
    CA3 Mossy Fiber-Associated Basket CCK+*
    CA3 Bistratified
    CA3 Ivy
    CA3 Bilayer Ivy*
    CA3 LMR-Targeting
    CA3 Lucidum*
    CA3 Lucidum LAX
    CA3 Lucidum ORAX
    CA3 Lucidum-Radiatum
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 O-LM
    CA3 Perforant Path-Associated Projecting*
    CA3 Radiatum
    CA3 SO-SO
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Wide-Arbor Basket
    CA1 Back-Projection
    CA1 RO-receiving CA3-targeting*

    Potential sources known to be avoided
    Excitatory or Inhibitory
    CA3 Interneuron Specific Oriens
    CA3 Interneuron Specific Quad

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    DG Mossy
    CA3c Pyramidal
    CA1 LMR

    Potential targets
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Mossy MOLDEN
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Axo-axonic GRALDEN*
    DG Basket
    DG Basket GRALDEN*
    DG Basket CCK+
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG Interneuron Specific HIPRO*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG Wide-Arbor Neurogliaform*
    CA3 Pyramidal
    CA3 Athorny Pyramidal*
    CA3c Umbrella Pyramidal*
    CA3 Giant
    CA3 Granule
    CA3 Axo-axonic
    CA3 Horizontal Axo-axonic
    CA3 Basket
    CA3 Basket CCK+
    CA3 Horizontal Basket CCK+*
    CA3 Mossy Fiber-Associated Basket CCK+*
    CA3 Bistratified
    CA3 Ivy
    CA3 LMR-Targeting
    CA3 Lucidum LAX
    CA3 Lucidum ORAX
    CA3 Lucidum-Radiatum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 O-LM
    CA3 Recurrent O-LM*
    CA3 Interneuron Specific Oriens
    CA3 Perforant Path-Associated*
    CA3 Perforant Path-Associated Projecting*
    CA3 Interneuron Specific Quad
    CA3 QuadD-LM
    CA3 Radiatum
    CA3 R-LM
    CA3 SO-SO
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Basket
    CA2 Wide-Arbor Basket
    CA2 Bistratified
    CA2 SP-SR
    CA1 Pyramidal
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Radiatum Giant
    CA1 Axo-axonic
    CA1 Horizontal Axo-axonic
    CA1 Back-Projection
    CA1 Basket
    CA1 Horizontal Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Basket CCK+
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 RO-receiving CA3-targeting*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 O-LM
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens/Alveus
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar
    Sub CA1-Projecting Pyramidal
    Sub EC-Projecting Pyramidal
    Sub Axo-axonic

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value
    Theta (deg):-58.63
    Theta range:[-58.63, 299.12]
    Theta measurements:2
    Theta representative selection:   rats, adult, male,
    silicon probe, freely moving
    SWR ratio:1.70
    SWR ratio range:[1.70, 1.70]
    SWR ratio measurements:1
    SWR ratio representative selection:   rats, adult, male and female,
    sharp pipette, urethane
    In vivo firing rate (Hz):0.28
    Firing rate range:[0.28, 0.28]
    Firing rate measurements:1
    Firing rate representative selection:   rats, adult, male,
    silicon probe, freely moving
    Other:DS_ratio and 7 others
    Other representative selection:   rats, adult, male and female,
    sharp pipette, urethane