CA3 Pyramidal
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
CA3 (e)23223p-CA2_0101-CA1_0101 Pyramidal S040402:Glutamatergic PC:Pyramidal:CA3

Name derivation
This is a canonical principal cell of the main hippocampal circuit. CA3 distinguishes these cells from pyramidal cells in other subregions.

Synonym(s)
CA3 pyramidal cell
CA3a pyramidal cell
CA3a pyramidal neuron
CA3b pyramidal cell
distal CA3 pyramidal cell
mid CA3 pyramidal cell
more distal CA3 pyramidal cell
pyramidal cell located in distal CA3
pyramidal cell located in mid CA3

List of articles
Click here to view the list
Amaral D  (2007) The Hippocampus Book
Hippocampal Neuroanatomy
Amaral D, Lavenex P.
The Hippocampus Book, 2007, Pages: 35 - 112
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Amaral DG  (2007) Prog Brain Res
The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies).
Amaral DG, Scharfman HE, Lavenex P.
Prog Brain Res, 2007, 163, Pages: 3 - 22
PMID: 17765709; DOI: 10.1016/S0079-6123(07)63001-5
Tags: morphology, connectivity, synapse probabilities
Bernard C  (1994) Hippocampus
Model of local connectivity patterns in CA3 and CA1 areas of the hippocampus.
Bernard C, Wheal HV.
Hippocampus, 1994 Oct, 4 (5), Pages: 497 - 529
PMID: 7889123; DOI: 10.1002/hipo.450040502
Tags: morphology, connectivity, synapse probabilities
Fernandez-Lamo I  (2019) Cell Reports
Proximodistal Organization of the CA2 Hippocampal Area
Fernandez-Lamo I, Gomez-Dominguez D, Sanchez-Aguilera A, Oliva A, Morales AV, Valero M, Cid E, Berenyi A, de la Prida LM.
Cell Reports, 2019, Pages: 1734 - 1746
PMID: 30759386
Tags: phases
Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities
Ishizuka N  (1990) J Comp Neurol
Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat.
Ishizuka N, Weber J, Amaral DG.
J Comp Neurol, 1990 May 22, 295 (4), Pages: 580 - 623
PMID: 2358523; DOI: 10.1002/cne.902950407
Tags: morphology, synapse probabilities
Jaffe DB  (2007) Prog Brain Res
Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3.
Jaffe DB, Gutierrez R.
Prog Brain Res, 2007, 163, Pages: 109 - 132
PMID: 17765714; DOI: 10.1016/S0079-6123(07)63006-4
Tags: morphology, connectivity, synapse probabilities
Lasztoczi B  (2011) J Neurosci
Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
Lasztoczi B, Tukker JJ, Somogyi P, Klausberger T.
J Neurosci, 2011 Dec 7, 31 (49), Pages: 18073 - 18093
PMID: 22159120; DOI: 10.1523/JNEUROSCI.3573-11.2011
Tags: phases
Leranth C  (2007) Prog Brain Res
Extrinsic afferent systems to the dentate gyrus.
Leranth C, Hajszan T.
Prog Brain Res, 2007, 163, Pages: 63 - 84
PMID: 17765712; DOI: 10.1016/S0079-6123(07)63004-0
Tags: morphology, connectivity, synapse probabilities
Li XG  (1994) J Comp Neurol
The hippocampal CA3 network: an in vivo intracellular labeling study.
Li XG, Somogyi P, Ylinen A, Buzsaki G.
J Comp Neurol, 1994 Jan 8, 339 (2), Pages: 181 - 208
PMID: 8300905; DOI: 10.1002/cne.903390204
Tags: morphology, connectivity, synapse probabilities
Mizuseki K  (2009) Neuron
Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop.
Mizuseki K, Sirota A, Pastalkova E, Buzsaki G.
Neuron, 2009, Pages: 267 - 280
PMID: 19874793
Tags: phases
Oliva A  (2016) Hippocampus
Spatial Coding and Physiological Properties of Hippocampal Neurons in the Cornu Ammonis Subregions
Oliva A, Fernandez-Ruiz A, Buzsaki G, Berenyi A.
Hippocampus, 2016, Pages: 1593 - 1607
PMID: 27650887
Tags: phases
Perez-Rosello T  (2011) Journal of Computational Neuroscience
Passive and active shaping of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells
Perez-Rosello T, Baker JL, Ferrante M, Iyengar S, Ascoli GA, Barrionuevo G.
Journal of Computational Neuroscience, 2011, 31 (2), Pages: 159 - 182
PMID: 21207127; DOI: 10.1007/s10827-010-0303-y
Tags: morphology, firing patterns
Sanchez-Aguilera A  (2021) PLoS Biology
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo
Sanchez-Aguilera A, Wheeler DW, Jurado-Parras T, Valero M, Nokia MS, Cid E, Fernandez-Lamo I, Sutton N, Garcia-Rincon D, de la Prida LM, Ascoli GA.
PLoS Biology, 2021, 19 (5), Pages: 1 - 28
PMID: 33956790; DOI: 10.1371/journal.pbio.3001213
Tags: phases
Senzai Y  (2017) Neuron
Physiological Properties and Behavioral Correlates of Hippocampal Granule Cells and Mossy Cells.
Senzai Y, Buzsaki G..
Neuron, 2017, Pages: 691 - 704
PMID: 28132824
Tags: phases
Seress L  (2007) Prog Brain Res
Comparative anatomy of the hippocampal dentate gyrus in adult and developing rodents, non-human primates and humans.
Seress L.
Prog Brain Res, 2007, 163, Pages: 23 - 41
PMID: 17765710; DOI: 10.1016/S0079-6123(07)63002-7
Tags: morphology, marker, connectivity, synapse probabilities
Spruston N  (2007) The Hippocampus Book
Chapter 5: Structural and functional properties of hippocampal neurons
Spruston N, McBain C.
The Hippocampus Book, 2007, Pages: 133 - 200
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Szabadics J  (2009) J Neurosci
Functional specificity of mossy fiber innervation of GABAergic cells in the hippocampus.
Szabadics J, Soltesz I.
J Neurosci, 2009 Apr 1, 29 (13), Pages: 4239 - 4251
PMID: 19339618; DOI: 10.1523/JNEUROSCI.5390-08.2009
Tags: morphology, connectivity, synapse probabilities
Tamamaki N  (1991) Journal of Comparative Neurology
Crossing fiber arrays in the rat hippocampus as demonstrated by three-dimensional reconstruction
Tamamaki N, Nojyo Y.
Journal of Comparative Neurology, 1991, 303 (3), Pages: 435 - 442
PMID: 2007659; DOI: 10.1002/cne.903030309
Tags: synapse probabilities
Tukker JJ  (2013) J Neurosci.
Distinct Dendritic Arborization and in Vivo Firing Patterns of Parvalbumin-Expressing Basket Cells in the Hippocampal Area CA3
Tukker JJ, Lasztoczi B, Katona L, Roberts JDB, Pissadaki EK, Dalezios Y, Marton L, Zhang L, Klausberger T, Somogyi P.
J Neurosci., 2013, Pages: 6809 - 6825
PMID: 23595740
Tags: phases
Turner DA  (1995) Journal of Comparative Neurology
Morphometric and electrical properties of reconstructed hippocampal CA3 neurons recorded in vivo
Turner DA, Li XG, Pyapali GK, Ylinen A, Buzsaki G..
Journal of Comparative Neurology, 1995, 356 (4), Pages: 580 - 594
PMID: 7560268; DOI: 10.1002/cne.903560408
Tags: synapse probabilities
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities
Winnubst J  (2019) Cell
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain
Winnubst J, Bas E, Ferreira TA, Wu Z, Economo MN, Edson P, Arthur BJ, Bruns C, Rokicki K, Schauder D, Olbris DJ, Murphy SD, Ackerman DG, Arshadi C, Baldwin P, Blake R, Elsayed A, Hasan M, Ramirez D, Dos Santos B, Weldon M, Zafar A, Dudman JT, Gerfen CR, Hantman AW, Korff W, Sternson SM, Spruston N, Svoboda K, Chandrashekar J..
Cell, 2019, 179 (1), Pages: 268 - 281
PMID: 31495573; DOI: 10.1016/j.cell.2019.07.042
Tags: synapse probabilities
Witter MP  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Connectivity of the Hippocampus
Witter MP.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 5 - 26
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Amaral
  • Ascoli
    • ca3b (fits the general description of "CA3 Pyramidal" cells)
  • Barrionuevo
  • Bullmann
  • Heistek_Mansvelder
    • 110412-s3-1 (fits the general description of "CA3 Pyramidal" cells)
  • Henckens
  • Hunt
  • Jaffe
  • Jonas
  • Kanatsou
  • Mallick
  • MouseLight
  • Peng
  • Si_Wang
  • Turner
  • Vidal
  • Wittner

  • Morphology
    Soma
    CA3:SP
    Axons
    CA3:SR
    CA3:SO
    CA2:SR
    CA2:SO
    CA1:SR
    CA1:SO
    Dendrites
    CA3:SLM
    CA3:SR
    CA3:SL
    CA3:SP
    CA3:SO

    Representative figure
    Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat.
    Ishizuka N, Weber J, Amaral DG
    J Comp Neurol, 1990 May 22, 295 (4), pages: 580 - 623
    PMID: 2358523; DOI: 10.1002/cne.902950407


    "Fig. 1. Camera lucida drawing of a CA3 pyramidal cell {CA3 Pyramidal} intracellularly labeled with HRP [horseradish peroxidase]. ... The principal axon was cut in stratum oriens shortly after its origin and is marked by a larger circle. ... Arrows delimit the CA2 field of the hippocampus."


    Molecular markers
    Positive
    alpha-actinin-2
    BDNF
    Bok
    Caln
    CaM
    Disc1
    GABA-B1
    GABAa\alpha 4
    GABAa\alpha 5
    GluA1
    Man1a (weak positive)
    Math-2
    mGluR1
    mGluR5
    Mus1R
    Mus3R
    Neuropilin2
    NG
    p-CREB
    SCIP
    vGlut1
    VILIP
    Y2
    Negative
    5HT-3
    AR-beta1
    CB
    CGRP
    CR
    ENK
    ErbB4
    GABAa \delta
    GABAa\alpha 3
    GABAa\alpha 6 (confirmed by inference)
    GABAa\gamma 1
    GAT-3
    GAT-1
    GlyT2
    Id-2
    Kv3.1
    mGluR1a (confirmed by inference)
    mGluR2
    mGluR2/3
    mGluR3
    Mus2R
    NKB
    NPY
    PCP4
    PPTA
    Prox1
    PV
    RLN
    SATB1
    SOM (confirmed by inference)
    Sub P Rec
    TH
    vAChT
    vGAT
    VIP
    Mixed expression
    AMIGO2 (subtypes)
    CB1 (unresolved)
    CCK (unresolved)
    CoupTF II (subtypes)
    GABAa\alpha 2 (subcellular expression differences)
    GABAa\beta 1 (subcellular expression differences)
    GABAa\beta 2 (subcellular expression differences)
    GABAa\beta 3 (subcellular expression differences)
    GABAa\gamma 2 (subcellular expression differences)
    Gaba-a-alpha (subcellular expression differences)
    mGluR5a (subcellular expression differences)
    nNOS (species/protocol differences)
    vGluT3 (species/protocol differences)

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -60.5±5.4 mV (43); 8 sources (167): [-74.4 , -55.6]
    Input resistance (Rin): 126±8 MΩ (35); 8 sources (125): [23.2 , 307]
    Action potential amplitude (APampl): 97.6±1.9 mV (43); 4 sources (54): [80 , 97.6]
    Action potential width (APwidth): 1±0.1 ms (43); 4 sources (56): [0.71 , 1.7]
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 7.5 mV (1); 3 sources (14): [7.5 , 8.2]
    Sag ratio: 1.01±0.01 (7); 4 sources (12): [0.81 , 1.01]
    Time constant (τm): 61±24 ms (36); 7 sources (158): [12.5 , 71]
    Threshold potential (Vthresh): 28 mV (1); 3 sources (3): [13 , 28]
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 10.2±0.5 mV (43); 3 sources (48): [2 , 10.2]
    Max firing rate (Max F.R.): 40±20.8 Hz (3); 1 source

    Notes

    CA3 (e)23223p Pyramidal cells (CA3 PC) [2000]

    Related types: CA3c (e)23223p-DG_0001-CA2_0100-CA1_0100 Umbrella Pyramidal (v2.0 active)
    CA3c (e)03223p-DG_0101-CA2_0101-CA1_0101-Sub_100 Pyramidal (v1.0 active)
    CA3 (e)22223 Athorny Pyramidal (v2.0 active)

    Supplement notes:

    DWW 05/23/2023

    Based on dendrites alone it would be 22222, but since this is a CA3 PC without the axons included in the reconstruction, I would concur with the 23223 AD pattern. - JDK 05/23/2023

    approved. - GAA 05/24/2023

    Firing Pattern
    Images
    Image MissingImage MissingImage MissingImage MissingImage MissingImage MissingImage MissingImage Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]
    ASP.NASP [Evidence] [Firing Pattern]
    NASP [Evidence] [Firing Pattern]
    PSWB [Evidence] [Firing Pattern]
    RASP.NASP [Evidence] [Firing Pattern]
    TSTUT. [Evidence] [Firing Pattern]
    TSWB.SLN [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=0.79;a= 0.008;b= -42.55;d= 588;C= 366;Vr= -63.2;Vt= -33.6;Vpeak= 35.86;Vmin= -38.87; Simulate
    subtype: 2 k=0.54;a= 0.004;b= 5.21;d= 48;C= 297;Vr= -60.53;Vt= -21.24;Vpeak= 38.02;Vmin= -36.52; Simulate
    subtype: 3 k=0.98;a= 0.008;b= 12.49;d= 138;C= 382;Vr= -58.63;Vt= -42.74;Vpeak= 38.55;Vmin= -34.52; Simulate
    subtype: 4 k=0.8;a= 0.006;b= 24.13;d= 13;C= 41;Vr= -55.36;Vt= -20.09;Vpeak= 15.09;Vmin= -39.36; Simulate
    subtype: 5 k=1.61;a= 0.019;b= 11.16;d= 26;C= 30;Vr= -60.49;Vt= -33.22;Vpeak= 37.51;Vmin= -39.75; Simulate
    subtype: 6 k=2.5;a= 0.019;b= 23.05;d= 61;C= 87;Vr= -60.52;Vt= -40.38;Vpeak= 37.06;Vmin= -53.63; Simulate
    Images
    Image MissingImage MissingImage MissingImage MissingImage MissingImage Missing
    ModelDB Model
    Model Accession Number PubMed ID
    137259 21191641
    240961 29768258
    126814 21423487
    118098 19232379
    225906 21452258
    225906 28460009
    253369 30897846
    189088 27221619
    138421 16141320
    142104 23678009
    151282 24204609
    147867 20457854
    139421 21832203
    120907 20387109
    243350 30382451
    135903 21273309
    147756 15563748
    168314 24978936

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    DG Granule
    CA3 Pyramidal
    CA3 Granule
    CA3 Axo-axonic
    CA3 Horizontal Axo-axonic
    CA3 Basket
    CA3 Basket CCK+
    CA3 Bistratified
    CA3 Ivy
    CA3 Lucidum-Radiatum
    CA3 Mossy Fiber-Associated ORDEN
    CA3 O-LM
    CA3 QuadD-LM
    CA3 Radiatum
    CA1 Back-Projection
    MEC LII Stellate

    Potential sources
    Excitatory or Inhibitory
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG HIPROM
    CA3 Athorny Pyramidal*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Giant
    CA3 Horizontal Basket CCK+*
    CA3 Mossy Fiber-Associated Basket CCK+*
    CA3 Bilayer Ivy*
    CA3 LMR-Targeting
    CA3 Lucidum*
    CA3 Lucidum LAX
    CA3 Lucidum ORAX
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 Recurrent O-LM*
    CA3 Perforant Path-Associated*
    CA3 Perforant Path-Associated Projecting*
    CA3 R-LM
    CA3 SO-SO
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Wide-Arbor Basket
    CA1 RO-receiving CA3-targeting*

    Potential sources known to be avoided
    Excitatory or Inhibitory
    CA3 Interneuron Specific Oriens
    CA3 Interneuron Specific Quad

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    CA3 Pyramidal
    CA3 Axo-axonic
    CA3 Basket
    CA3 Ivy
    CA3 Mossy Fiber-Associated ORDEN
    CA1 Pyramidal
    CA1 Axo-axonic
    CA1 Basket
    CA1 Basket CCK+
    CA1 LMR
    CA1 O-LM
    CA1 Oriens/Alveus

    Potential targets
    Excitatory or Inhibitory
    CA3 Athorny Pyramidal*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Giant
    CA3 Granule
    CA3 Horizontal Axo-axonic
    CA3 Basket CCK+
    CA3 Horizontal Basket CCK+*
    CA3 Mossy Fiber-Associated Basket CCK+*
    CA3 Bistratified
    CA3 LMR-Targeting
    CA3 Lucidum LAX
    CA3 Lucidum ORAX
    CA3 Lucidum-Radiatum
    CA3 Mossy Fiber-Associated
    CA3 O-LM
    CA3 Recurrent O-LM*
    CA3 Interneuron Specific Oriens
    CA3 Perforant Path-Associated*
    CA3 Perforant Path-Associated Projecting*
    CA3 Interneuron Specific Quad
    CA3 QuadD-LM
    CA3 Radiatum
    CA3 R-LM
    CA3 SO-SO
    CA3 Trilaminar
    CA2 Pyramidal
    CA2 Basket
    CA2 Wide-Arbor Basket
    CA2 Bistratified
    CA2 SP-SR
    CA1 Deep Pyramidal
    CA1 Superficial Pyramidal
    CA1 Radiatum Giant
    CA1 Horizontal Axo-axonic
    CA1 Back-Projection
    CA1 Horizontal Basket
    CA1 R-P Basket*
    CA1 Trilayer Basket*
    CA1 Vertical Basket*
    CA1 Horizontal Basket CCK+*
    CA1 Trilayer Basket CCK+*
    CA1 Bistratified
    CA1 RO-receiving CA3-targeting*
    CA1 Hippocampo-subicular Projecting ENK+
    CA1 Ivy
    CA1 Interneuron Specific LMO-O
    CA1 LMR-LM*
    CA1 Interneuron Specific LMR-O*
    CA1 LMR-R*
    CA1 Interneuron Specific LMR-R
    CA1 LMR Projecting
    CA1 Recurrent O-LM
    CA1 O-LMR
    CA1 Recurrent O-LMR*
    CA1 Interneuron Specific O-R
    CA1 O-RP*
    CA1 Interneuron Specific O-Targeting QuadD
    CA1 Oriens-Bistratified
    CA1 Oriens-QuadA Projecting
    CA1 OR-LM
    CA1 O-RPO*
    CA1 Perforant Path-Associated
    CA1 Perforant Path-Associated QuadD
    CA1 QuadD-RP*
    CA1 Quadrilaminar
    CA1 Interneuron Specific R-O
    CA1 R-Receiving Apical-Targeting
    CA1 R-RO*
    CA1 R-RP*
    CA1 Radiatum
    CA1 Interneuron Specific RO-O
    CA1 Interneuron Specific RO-R*
    CA1 RO-RP*
    CA1 RP-RPO*
    CA1 Schaffer Collateral-Associated
    CA1 Schaffer Collateral-Correlated*
    CA1 Schaffer Collateral-Receiving R-Targeting
    CA1 SO-SO
    CA1 SO-SO Projecting*
    CA1 Trilaminar
    CA1 Radial Trilaminar

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value
    Theta (deg):78.78
    Theta range:[78.78, 78.78]
    Theta measurements:1
    Theta representative selection:   mice, adult, unknown sex,
    optotagging, freely moving
    SWR ratio:1.10
    SWR ratio range:[1.10, 1.10]
    SWR ratio measurements:1
    SWR ratio representative selection:   rats, adult, male and female,
    sharp pipette, urethane
    In vivo firing rate (Hz):0.69
    Firing rate range:[0.69, 0.69]
    Firing rate measurements:1
    Firing rate representative selection:   mice, adult, unknown sex,
    optotagging, freely moving
    Other:DS_ratio and 8 others
    Other representative selection:   rats, adult, male and female,
    sharp pipette, urethane