DG Interneuron Specific COLTAR*
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)2101 Interneuron Specific COLTAR* S091201:Interneuron Specific:IS:DG

Name derivation
This is a new name derived from the interneuron specificity and is in the vein of HICAP, MOPP, and HIPP that stands for "COLlateral-TARgeting."

Synonym(s)
DG bistratified cell

List of articles
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Wei YT  (2021) Journal of Comparative Neurology
Morpho-physiological properties and connectivity of vasoactive intestinal polypeptide-expressing interneurons in the mouse hippocampal dentate gyrus
Wei YT, Wu JW, Yeh CW, Shen HC, Wu KP, Vida I, Lien CC.
Journal of Comparative Neurology, 2021, 529 (10), Pages: 2658 - 2675
PMID: 33484471; DOI: 10.1002/cne.25116
Tags: morphology, marker, membrane biophysics

List of Hippocampome.org to NeuroMorpho.Org mappings
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  • Lien

    • Morphology
    Soma
    DG:SMo
    DG:SMi
    Axons
    DG:SMi
    DG:H
    Dendrites
    DG:SMo

    Representative figure
    Morpho-physiological properties and connectivity of vasoactive intestinal polypeptide-expressing interneurons in the mouse hippocampal dentate gyrus
    Wei YT, Wu JW, Yeh CW, Shen HC, Wu KP, Vida I, Lien CC
    Journal of Comparative Neurology, 2021, 529 (10), pages: 2658 - 2675
    PMID: 33484471; DOI: 10.1002/cne.25116


    "FIGURE 3 Morpho-physiological classification of VIP+ INs. (a) Top, exemplar reconstructions of a hilus-projecting (HP) cell with axonal projections to the hilus; molecular layer-projecting (MP) cell with axonal distributions in the inner two-thirds of the molecular layer; bistratified (Bis) cell {DG Interneuron Specific COLTAR*} with axonal plexus distributed in the inner one-third of the molecular layer and hilus; trilamilar (Tri) cell with axonal arborization across the three layers. Somata and dendrites were in black. Axons of HP, MP, Bis and Tri cells were in red, blue, purple, and orange, respectively."


    Molecular markers
    Positive
    VIP
    Negative
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (multiple confirming inferences)
    mGluR1a (inference)
    PV (inference)
    SOM (multiple confirming inferences)
    vGluT3 (inference)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -60.8±3.8 mV (4); 1 source
    Input resistance (Rin): 812±155 MΩ (4); 1 source
    Threshold potential (Vthresh): 22.9±6.3 mV (4); 1 source
    Action potential amplitude (APampl): 75.7±3.2 mV (4); 1 source
    Action potential width (APwidth): 0.91±0.11 ms (4); 1 source
    Max firing rate (Max F.R.): 30.3±4.9 Hz (4); 1 source

    Notes

    DG (i)2101 Interneuron-Specific Collateral-Targeting (IS COLTAR) cells [1104]

    Related types: DG (i)2313p-CA3_03000-CA1_2000 IS-3 projection (v1.0 on-hold)
    DG (i)2303 non-FS interneuron (v1.0 on-hold)

    Notes: This type has no dendrites in DG:SMi_H, which distinguishes it from the v1.0 neuron types. This type does not project into CA3, which distinguishes it from the other IS projection type. These cells are VIP+ and are speculated by the authors to be interneuron specific.

    VIP+. Ephys. FP. Lengths.

    After reviewing DG (i)2101p IS COLTAR Proj [#1104], I am unsure where the evidence of projection to CA1 SLM for this neuron type is coming from. Is this an inference made based off evidence from the on-hold IS-3 projection neuron type? Otherwise I am not seeing any textual evidence or evidence from the provided figures to support this conclusion (Figure 3b from the provided packet does not support a projection to CA1 based on somata locations relative to CA1 in our reference van Strien figure). - JDK 11/22/2021

    When I look at the possible somata locations for each of the four Bis neurons as shown in 3b I donā??t think any of them would be positioned to extend into CA1 SLM. - JDK 11/23/2021

    It is hard to judge based on no information from the authors, but they definitely project outside of the DG.
    You would picture them projecting more into the subiculum or the presubiculum? - DWW 11/23/2021

    I concur they definitely project outside of DG. And ahh I see, noted on what you had in mind.
    Yes I could see them projecting to either subiculum SM or presubiculum based on the somata locations provided by the reference. - JDK 11/23/2021

    After taking a closer look at the somata location provided by the authors and comparing their schematic to Figure 1C of van Strien et al., 2009, I think we have been too conservative in our assessment of the somata locations. I now think they are more parallel to the presubiculum and parasubiculum than to the subiculum. - DWW 11/30/2021

    I can see this being the case. With that said, should we just not include that it projects? This would constitute a new neuron type just from its A-D pattern in DG. - JDK 11/30/2021

    I agree that we should still include this as a new neuron type. I will add comments that the dendrites project outside of the entire hippocampal formation and, therefore, will not be considered in the A-D pattern. - DWW 12/01/2021

    I agree with the proposed solution. - JDK 12/02/2021

    I approve. Only requested change, remove the p-CA1_2000 appendix from the formal name on page 1 of the packet in light of the notes thereafter. - GAA 01/25/2022

    Firing Pattern
    Images
    No image is associated with this neuron
    Parameters
    No parameter associated with this neuron
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    none known

    Potential sources
    Excitatory or Inhibitory
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG COM-MOPP*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG HIPROM
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA3 Spiny Lucidum
    CA3 Perforant Path-Associated Projecting*
    CA1 Local-Projecting Cajal-Retzius*
    CA1 LMR Projecting
    CA1 Neurogliaform Projecting
    CA1 Perforant Path-Associated
    EC LI-II Pyramidal-Fan
    MEC LII Stellate
    EC LII-III Pyramidal-Tripolar
    EC LIV-V Pyramidal-Horizontal
    MEC LV Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    none known

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    none known

    Potential targets
    Excitatory or Inhibitory
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Axo-axonic GRALDEN*
    DG Basket
    DG Basket GRALDEN*
    DG Basket CCK+
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG Interneuron Specific HIPRO*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG Wide-Arbor Neurogliaform*
    CA3 Interneuron Specific Quad

    Potential targets known to be avoided
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Mossy
    DG Mossy MOLDEN

    Oscillation Phase Locking
    Category
    Value