DG Hilar Ectopic Granule
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (e)2203p-CA3_00100 Hilar Ectopic Granule S010101:Glutamatergic GC:Granule:DG

Name derivation
This is the most descriptive of the related names in the cited literature.

Synonym(s)
DG ectopic granule cell
DG ectopic granule cell in the hilus
DG ectopic granule-like cell in the hilar region
DG ectopic hilar granule cell
DG EGC
DG hilar EGC

List of articles
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Marti-Subirana A  (1986) J Anat
Morphological aspects of the ectopic granule-like cellular populations in the albino rat hippocampal formation: a Golgi study.
Marti-Subirana A, Soriano E, Garcia-Verdugo JM.
J Anat, 1986 Feb, 144, Pages: 31 - 47
PMID: 2447048
Tags: morphology, connectivity
McCloskey DP  (2006) Eur J Neurosci
Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat.
McCloskey DP, Hintz TM, Pierce JP, Scharfman HE.
Eur J Neurosci, 2006 Oct, 24 (8), Pages: 2203 - 2210
PMID: 17042797; DOI: 10.1111/j.1460-9568.2006.05101.x
Tags: morphology
Pierce JP  (2011) J Comp Neurol
Morphometry of hilar ectopic granule cells in the rat.
Pierce JP, McCloskey DP, Scharfman HE.
J Comp Neurol, 2011 Apr 15, 519 (6), Pages: 1196 - 1218
PMID: 21344409; DOI: 10.1002/cne.22568
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities
Scharfman HE  (2003) Neuroscience
Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures.
Scharfman HE, Sollas AE, Berger RE, Goodman JH, Pierce JP.
Neuroscience, 2003, 121 (4), Pages: 1017 - 1029
PMID: 14580952
Tags: morphology, membrane biophysics, connectivity, firing patterns, synapse probabilities
Scharfman HE  (2012) Epilepsia
New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction.
Scharfman HE, Pierce JP.
Epilepsia, 2012 Jun, 53 Suppl 1, Pages: 109 - 115
PMID: 22612815; DOI: 10.1111/j.1528-1167.2012.03480.x
Tags: morphology, connectivity


Morphology
Soma
DG:H
Axons
DG:H
CA3:SL
Dendrites
DG:SMo
DG:SMi
DG:H

Molecular markers
Positive
None known
Negative
GABAa\alpha 6 (inference)
Mixed expression
None known

Electrophysiological properties
Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

Sag ratio: 0.99 (1); 1 source
Threshold potential (Vthresh): 30 mV (1); 1 source
Fast afterhyperpolaziring potential amplitude (Fast AHP): 6.8 mV (1); 1 source
Action potential amplitude (APampl): 75 mV (1); 1 source
Max firing rate (Max F.R.): >68 Hz (1); 1 source


Firing Pattern
Images
Image MissingImage Missing
Parameters View page
ASP. [Evidence] [Firing Pattern]
RASP. [Evidence] [Firing Pattern]
TSWB.SLN [Evidence] [Firing Pattern]

Izhikevich Model
Parameters Single Compartment Downloads Simulate
subtype: 1 k=2.9;a= 0.006;b= 6.17;d= 186;C= 483;Vr= -70.37;Vt= -55.22;Vpeak= -37.82;Vmin= -62.23; Simulate
subtype: 2 k=1.82;a= 0.002;b= -1.08;d= 54;C= 63;Vr= -70.86;Vt= -36.29;Vpeak= -11.37;Vmin= -53.29; Simulate
Images
Image MissingImage Missing
ModelDB Model
Model Accession Number PubMed ID

Sources of Input
Known sources
Excitatory or Inhibitory
DG Granule

Potential sources
Excitatory or Inhibitory
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Semilunar Granule
DG Cajal-Retzius*
DG Local-Projecting Cajal-Retzius*
DG Mossy
DG Mossy MOLDEN
DG AIPRIM
DG Axo-axonic
DG COM-MOPP*
DG HICAP
DG Hilus-Associated Interneuron*
DG HIPP
DG Recurrent HIPP*
DG HIPP-CAP*
DG Recurrent HIPP-CAP*
DG HIPROM
DG Ivy*
DG MOCAP
DG MOLAX
DG Molecular Layer*
DG Outer Molecular Layer
DG Total Molecular Layer
DG MOPP
DG Neurogliaform
DG Wide-Arbor Neurogliaform*
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Perforant Path-Associated Projecting*
CA2 Pyramidal
CA1 Local-Projecting Cajal-Retzius*
CA1 Back-Projection
CA1 LMR Projecting
CA1 Neurogliaform Projecting
CA1 Perforant Path-Associated
EC LI-II Pyramidal-Fan
MEC LII Stellate
EC LII-III Pyramidal-Tripolar
EC LIV-V Pyramidal-Horizontal
MEC LV Pyramidal

Potential sources known to be avoided
Excitatory or Inhibitory
DG Interneuron Specific COLTAR*
DG Interneuron Specific IMOT*
DG Interneuron Specific HIMOLD*
DG Interneuron Specific HIPRO*
CA3 Interneuron Specific Quad

Targets of Output
Known targets
Excitatory or Inhibitory
none known

Potential targets
Excitatory or Inhibitory
DG Adult-Born Immature Granule*
DG Hilar Ectopic Granule
DG Mossy
DG Mossy MOLDEN
DG AIPRIM
DG Axo-axonic
DG Granulosum-targeting Axo-axonic*
DG Basket
DG Basket CCK+
DG HICAP
DG Interneuron Specific IMOT*
DG Hilus-Associated Interneuron*
DG Interneuron Specific HIMOLD*
DG HIPP
DG Recurrent HIPP*
DG HIPP-CAP*
DG Recurrent HIPP-CAP*
DG HIPROM
DG Ivy*
DG MOLAX
DG Outer Molecular Layer
DG Total Molecular Layer
CA3 Pyramidal
CA3c Pyramidal
CA3c Umbrella Pyramidal*
CA3 Axo-axonic
CA3 Basket
CA3 Basket CCK+
CA3 Mossy Fiber-Associated Basket CCK+*
CA3 Bistratified
CA3 Ivy
CA3 Bilayer Ivy*
CA3 LMR-Targeting
CA3 Lucidum*
CA3 Lucidum LAX
CA3 Lucidum ORAX
CA3 Lucidum-Radiatum
CA3 Spiny Lucidum
CA3 Mossy Fiber-Associated
CA3 Mossy Fiber-Associated ORDEN
CA3 Interneuron Specific Quad
CA3 QuadD-LM

Potential targets known to be avoided
Excitatory or Inhibitory
none known

Oscillation Phase Locking
Category
Value