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* indicates new v2.0 neuron type Name Supertype (ID:Family:Type:Subregion) DG (i)1333p-CA3_01111 HIPROM S121001:O-LM Family:HIPP-like:DG Name derivation This is a new name derived from the cited descriptor in the vein of HICAP, MOPP, and HIPP that stands for "Hilar Interneuron with PRojections to the Outer Molecular layer." Synonym(s) DG aspiny hilar interneurons with projections to the outer molecular layer DG spiny hilar interneurons with projections to the outer molecular layer List of articles Click here to view the list Lubke J  (1998) J Neurophysiol Specialized electrophysiological properties of anatomically identified neurons in the hilar region of the rat fascia dentata. Lubke J, Frotscher M, Spruston N. J Neurophysiol, 1998 Mar, 79 (3), Pages: 1518 - 1534 PMID: 9497429 Tags: morphology, membrane biophysics, connectivity, firing patterns, synapse probabilities

Morphology

Soma
	DG:H

Axons
	DG:SMo
	DG:SMi
	DG:SG
	DG:H
	CA3:SR
	CA3:SL
	CA3:SP
	CA3:SO

Dendrites
	DG:SMi
	DG:SG
	DG:H

Representative figure

Specialized electrophysiological properties of anatomically identified neurons in the hilar region of the rat fascia dentata. Lubke J, Frotscher M, Spruston N J Neurophysiol, 1998 Mar, 79 (3), pages: 1518 - 1534 PMID: 9497429;

"FIG . 6. Paired morphology and physiology of a [dentate gyrus] spiny hilar interneuron {DG HIPROM}. A: morphology of the biocytin-filled neuron. Axonal projection (red) to the molecular layer is restricted mainly to the outer zone. Note abundant collaterals in the hilus and in area CA3c."

Molecular markers

Positive
	None known

Negative
	GABAa\alpha 6 (inference)

Mixed expression
	None known

Electrophysiological properties

	Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]
	Resting membrane potential (Vrest): -65±6 mV (3); 1 source
	Input resistance (Rin): 371±47 MΩ (3); 1 source
	Time constant (τm): 35 ms (2); 1 source
	Threshold potential (Vthresh): [25.1, 27.3] mV (2); 1 source
	Fast afterhyperpolaziring potential amplitude (Fast AHP): 13.1±3 mV (3); 1 source
	Action potential amplitude (APampl): 80.8 mV (1); 1 source
	Action potential width (APwidth): 0.72±0.08 ms (3); 1 source
	Max firing rate (Max F.R.): 69±4 Hz (3); 1 source
	Slow afterhyperpolarizing potential amplitude (Slow AHP): 3.1±1 mV (3); 1 source
	Sag ratio: 0.82±0.02 (3); 1 source

Notes

N = 3 cells are spiny, N = 4 cells are aspiny. Both spiny and aspiny cells are able to form basket-like bouton arrays on GC somata and somata of other hilar neurons. The youngest rats may be adolescents.

Firing Pattern

Images

Parameters		View page
	D.ASP.	[Evidence] [Firing Pattern]

Izhikevich Model

Parameters	Single Compartment	Downloads	Simulate
	subtype: 1 k=2.16;a= 0.001;b= -21.24;d= 28;C= 510;Vr= -65.4;Vt= -45.28;Vpeak= -9.92;Vmin= -49.31;	[FitFiles][CSV][XPP][Ensemble]	Simulate

Images

ModelDB Model

Model Accession Number

PubMed ID

Sources of Input

Known sources Excitatory or Inhibitory none known

Potential sources Excitatory or Inhibitory DG Granule DG Adult-Born Immature Granule* DG Hilar Ectopic Granule DG Semilunar Granule DG Mossy DG Mossy MOLDEN DG AIPRIM DG Granulosum-targeting Axo-axonic* DG Axo-axonic GRALDEN* DG Basket DG Basket GRALDEN* DG Basket CCK+ DG Interneuron Specific COLTAR* DG COM-MOPP* DG HICAP DG Interneuron Specific IMOT* DG Hilus-Associated Interneuron* DG Interneuron Specific HIMOLD* DG Recurrent HIPP* DG HIPP-CAP* DG Recurrent HIPP-CAP* DG Interneuron Specific HIPRO* DG HIPROM DG Ivy* DG MOCAP DG MOLAX DG Total Molecular Layer DG Wide-Arbor Neurogliaform* CA3c Pyramidal CA3c Umbrella Pyramidal* CA3 Spiny Lucidum CA3 Mossy Fiber-Associated CA3 Mossy Fiber-Associated ORDEN CA3 Perforant Path-Associated Projecting* CA3 Interneuron Specific Quad CA2 Pyramidal CA1 Back-Projection CA1 LMR Projecting MEC LV Pyramidal

Potential sources known to be avoided Excitatory or Inhibitory DG Axo-axonic

Targets of Output

Known targets Excitatory or Inhibitory DG Granule

Potential targets Excitatory or Inhibitory DG Adult-Born Immature Granule* DG Hilar Ectopic Granule DG Semilunar Granule DG Cajal-Retzius* DG Local-Projecting Cajal-Retzius* DG Mossy DG Mossy MOLDEN DG AIPRIM DG Axo-axonic DG Granulosum-targeting Axo-axonic* DG Axo-axonic GRALDEN* DG Basket DG Basket GRALDEN* DG Basket CCK+ DG Interneuron Specific COLTAR* DG COM-MOPP* DG HICAP DG Interneuron Specific IMOT* DG Hilus-Associated Interneuron* DG Interneuron Specific HIMOLD* DG HIPP DG Recurrent HIPP* DG HIPP-CAP* DG Recurrent HIPP-CAP* DG Interneuron Specific HIPRO* DG HIPROM DG Ivy* DG MOCAP DG MOLAX DG Molecular Layer* DG Outer Molecular Layer DG Total Molecular Layer DG MOPP DG Neurogliaform DG Wide-Arbor Neurogliaform* CA3 Pyramidal CA3 Athorny Pyramidal* CA3c Pyramidal CA3c Umbrella Pyramidal* CA3 Giant CA3 Granule CA3 Axo-axonic CA3 Horizontal Axo-axonic CA3 Basket CA3 Basket CCK+ CA3 Horizontal Basket CCK+* CA3 Mossy Fiber-Associated Basket CCK+* CA3 Bistratified CA3 Ivy CA3 Bilayer Ivy* CA3 LMR-Targeting CA3 Lucidum* CA3 Lucidum LAX CA3 Lucidum ORAX CA3 Lucidum-Radiatum CA3 Spiny Lucidum CA3 Mossy Fiber-Associated CA3 Mossy Fiber-Associated ORDEN CA3 O-LM CA3 Recurrent O-LM* CA3 Interneuron Specific Oriens CA3 Perforant Path-Associated* CA3 Perforant Path-Associated Projecting* CA3 Interneuron Specific Quad CA3 QuadD-LM CA3 Radiatum CA3 R-LM CA3 SO-SO CA3 Trilaminar CA2 Wide-Arbor Basket CA1 Neurogliaform Projecting

Potential targets known to be avoided Excitatory or Inhibitory none known

Oscillation Phase Locking

Category

Value