DG Axo-axonic
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)2233 Axo-axonic S110901:Perisomatic-targeting:Axo-axonic:DG

Name derivation
The phrase "chandelier cell" has fallen out of use. DG distinguishes these cells from axo-axonic cells in other subregions.

Synonym(s)
Dentate chandelier cell
DG AAC
DG axo-axonic cell
DG chandelier cell

List of articles
Click here to view the list
Amaral D  (2007) The Hippocampus Book
Hippocampal Neuroanatomy
Amaral D, Lavenex P.
The Hippocampus Book, 2007, Pages: 35 - 112
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Amaral DG  (2007) Prog Brain Res
The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies).
Amaral DG, Scharfman HE, Lavenex P.
Prog Brain Res, 2007, 163, Pages: 3 - 22
PMID: 17765709; DOI: 10.1016/S0079-6123(07)63001-5
Tags: morphology, connectivity, synapse probabilities
Dyhrfjeld-Johnsen J  (2007) J Neurophysiol
Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data.
Dyhrfjeld-Johnsen J, Santhakumar V, Morgan RJ, Huerta R, Tsimring L, Soltesz I.
J Neurophysiol, 2007 Feb, 97 (2), Pages: 1566 - 1587
PMID: 17093119; DOI: 10.1152/jn.00950.2006
Tags: morphology, connectivity, synapse probabilities
Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities
Halasy K  (1993) Eur J Neurosci
Subdivisions in the multiple GABAergic innervation of granule cells in the dentate gyrus of the rat hippocampus.
Halasy K, Somogyi P.
Eur J Neurosci, 1993 May 1, 5 (5), Pages: 411 - 429
PMID: 8261118; DOI: 10.1111/j.1460-9568.1993.tb00508.x
Tags: morphology, connectivity, synapse probabilities
Han ZS  (1993) Eur J Neurosci
A high degree of spatial selectivity in the axonal and dendritic domains of physiologically identified local-circuit neurons in the dentate gyrus of the rat hippocampus.
Han ZS, Buhl EH, Lorinczi Z, Somogyi P.
Eur J Neurosci, 1993 May 1, 5 (5), Pages: 395 - 410
PMID: 8261117; DOI: 10.1111/j.1460-9568.1993.tb00507.x
Tags: morphology, connectivity, synapse probabilities
Hosp JA  (2014) Hippocampus
Morpho-physiological criteria divide dentate gyrus interneurons into classes.
Hosp JA, Struber M, Yanagawa Y, Obata K, Vida I, Jonas P, Bartos M.
Hippocampus, 2014 Feb, 24 (2), Pages: 189 - 203
PMID: 24108530; DOI: 10.1002/hipo.22214
Tags: synapse probabilities
Houser CR  (2007) Prog Brain Res
Interneurons of the dentate gyrus: an overview of cell types, terminal fields and neurochemical identity.
Houser CR.
Prog Brain Res, 2007, 163, Pages: 217 - 232
PMID: 17765721; DOI: 10.1016/S0079-6123(07)63013-1
Tags: morphology, marker, connectivity, synapse probabilities
Morgan RJ  (2007) Prog Brain Res
Modeling the dentate gyrus.
Morgan RJ, Santhakumar V, Soltesz I.
Prog Brain Res, 2007, 163, Pages: 639 - 658
PMID: 17765743; DOI: 10.1016/S0079-6123(07)63035-0
Tags: morphology, connectivity, synapse probabilities
Morgan RJ  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Microcircuit Model of the Dentate Gyrus in Epilepsy
Morgan RJ, Soltesz I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 495 - 526
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities
Patton PE  (1995) Hippocampus
Connection matrix of the hippocampal formation: I. The dentate gyrus.
Patton PE, McNaughton B.
Hippocampus, 1995, 5 (4), Pages: 245 - 286
PMID: 8589792; DOI: 10.1002/hipo.450050402
Tags: morphology, connectivity, synapse probabilities
Ribak CE  (2007) Prog Brain Res
Ultrastructure and synaptic connectivity of cell types in the adult rat dentate gyrus.
Ribak CE, Shapiro LA.
Prog Brain Res, 2007, 163, Pages: 155 - 166
PMID: 17765717; DOI: 10.1016/S0079-6123(07)63009-X
Tags: morphology, marker, connectivity, synapse probabilities
Santhakumar V  (2008) Computational neuroscience in epilepsy
Modeling circuit alterations in epilepsy: A focus on mossy cell loss and mossy fiber sprouting in the dentate gyrus
Santhakumar V.
Computational neuroscience in epilepsy, 2008, Pages: 89 - 111
ISBN: 9780123736499
Tags: morphology, connectivity, synapse probabilities
Spruston N  (2007) The Hippocampus Book
Chapter 5: Structural and functional properties of hippocampal neurons
Spruston N, McBain C.
The Hippocampus Book, 2007, Pages: 133 - 200
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Bartos
    • hilarBC2 (fits the general description of "DG Axo-axonic" based on the distribution of axons and dendrites)
  • Jonas
    • BC3 (fits the general description of "DG Axo-axonic" based on the distribution of axons and dendrites)
  • Lien
    • 20111229-6-7 (fits the general description of "DG Axo-axonic" or "DG Basket" based on the distribution of axons and dendrites)
    • 20130609-1-4-PV
    • AAC (fits the general description of "DG Axo-axonic" based on the distribution of axons and dendrites)
  • McBain
    • 2009-12-08-1 (fits the general description of "DG Axo-axonic" based on the distribution of axons and dendrites)

    • Morphology
    Soma
    DG:SG
    Axons
    DG:SG
    DG:H
    Dendrites
    DG:SMo
    DG:SMi
    DG:SG
    DG:H

    Molecular markers
    Positive
    Gaba-a-alpha (inference)
    GAT-1
    PV
    Negative
    5HT-3 (inference)
    AR-beta1 (inference)
    AR-beta2 (inference)
    CB (multiple confirming inferences)
    CB1 (multiple confirming inferences)
    CCK (confirmed by inference)
    CGRP (inference)
    CR (multiple confirming inferences)
    GABAa\alpha 6 (inference)
    mGluR1a (inference)
    SOM (multiple confirming inferences)
    vGluT3 (inference)
    VIP (multiple confirming inferences)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Threshold potential (Vthresh): 13 mV (1); 2 sources (2): [8 , 13]
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 7 mV (1); 2 sources (11): [7 , 10.2]
    Action potential amplitude (APampl): 78 mV (1); 2 sources (2): [56.1 , 78]
    Action potential width (APwidth): 0.42 ms (1); 2 sources (14): [0.389 , 0.42]
    Max firing rate (Max F.R.): 85 Hz (1); 1 source
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 4.5 mV (1); 2 sources (2): [3.2 , 4.5]
    Resting membrane potential (Vrest): -65.1±3.9 mV (14); 1 source
    Input resistance (Rin): 73.9±23.8 MΩ (14); 1 source
    Time constant (τm): 7.7±3.8 ms (14); 1 source


    Firing Pattern
    Images
    Image MissingImage Missing
    Parameters View page
    NASP [Evidence] [Firing Pattern]
    RASP.NASP [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=1.52;a= 0.049;b= 12.27;d= -6;C= 77;Vr= -65.25;Vt= -54.35;Vpeak= 5.07;Vmin= -64.47; Simulate
    Images
    Image Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    DG Mossy

    Potential sources
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy MOLDEN
    DG AIPRIM
    DG Granulosum-targeting Axo-axonic*
    DG Basket
    DG Basket GRALDEN*
    DG Basket CCK+