DG HICAP
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)2322 HICAP S131101:Collateral-related:SMi-H-targeting:DG

Name derivation
This name best captures the essence of this mixture of less common and less formal cited names that stands for "HIlar Commissural-Associational Pathway-related."

Synonym(s)
DG CCK+ GPP cell
DG HICAP cell
DG hilar commissural-associational pathway related cell
DG IML cell
DG interneuron with inner molecular layer axons

List of articles
Click here to view the list
Amaral D  (2007) The Hippocampus Book
Hippocampal Neuroanatomy
Amaral D, Lavenex P.
The Hippocampus Book, 2007, Pages: 35 - 112
ISBN: 9780195100273
Tags: morphology, connectivity, synapse probabilities
Dyhrfjeld-Johnsen J  (2007) J Neurophysiol
Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data.
Dyhrfjeld-Johnsen J, Santhakumar V, Morgan RJ, Huerta R, Tsimring L, Soltesz I.
J Neurophysiol, 2007 Feb, 97 (2), Pages: 1566 - 1587
PMID: 17093119; DOI: 10.1152/jn.00950.2006
Tags: morphology, connectivity, synapse probabilities
Freund TF  (1996) Hippocampus
Interneurons of the hippocampus.
Freund TF, Buzsaki G.
Hippocampus, 1996, 6 (4), Pages: 347 - 470
PMID: 8915675; DOI: 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
Tags: morphology, connectivity, synapse probabilities
Han ZS  (1993) Eur J Neurosci
A high degree of spatial selectivity in the axonal and dendritic domains of physiologically identified local-circuit neurons in the dentate gyrus of the rat hippocampus.
Han ZS, Buhl EH, Lorinczi Z, Somogyi P.
Eur J Neurosci, 1993 May 1, 5 (5), Pages: 395 - 410
PMID: 8261117; DOI: 10.1111/j.1460-9568.1993.tb00507.x
Tags: morphology, marker, membrane biophysics, connectivity, firing patterns, synapse probabilities
Houser CR  (2007) Prog Brain Res
Interneurons of the dentate gyrus: an overview of cell types, terminal fields and neurochemical identity.
Houser CR.
Prog Brain Res, 2007, 163, Pages: 217 - 232
PMID: 17765721; DOI: 10.1016/S0079-6123(07)63013-1
Tags: morphology, connectivity, synapse probabilities
Liu YC  (2014) J Neurosci
Rapid dynamic changes of dendritic inhibition in the dentate gyrus by presynaptic activity patterns.
Liu YC, Cheng JK, Lien CC.
J Neurosci, 2014 Jan, 34 (4), Pages: 1344 - 1357
PMID: 24453325; DOI: 10.1523/JNEUROSCI.2566-13.2014
Tags: morphology, connectivity, synapse probabilities
Morgan RJ  (2007) Prog Brain Res
Modeling the dentate gyrus.
Morgan RJ, Santhakumar V, Soltesz I.
Prog Brain Res, 2007, 163, Pages: 639 - 658
PMID: 17765743; DOI: 10.1016/S0079-6123(07)63035-0
Tags: morphology, connectivity, synapse probabilities
Morgan RJ  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Microcircuit Model of the Dentate Gyrus in Epilepsy
Morgan RJ, Soltesz I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 495 - 526
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities
Mott DD  (1997) J Neurosci
Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity.
Mott DD, Turner DA, Okazaki MM, Lewis DV.
J Neurosci, 1997 Jun 1, 17 (11), Pages: 3990 - 4005
PMID: 9151716
Tags: morphology, marker, membrane biophysics, firing patterns, synapse probabilities
Patton PE  (1995) Hippocampus
Connection matrix of the hippocampal formation: I. The dentate gyrus.
Patton PE, McNaughton B.
Hippocampus, 1995, 5 (4), Pages: 245 - 286
PMID: 8589792; DOI: 10.1002/hipo.450050402
Tags: morphology, marker, connectivity, synapse probabilities
Santhakumar V  (2008) Computational neuroscience in epilepsy
Modeling circuit alterations in epilepsy: A focus on mossy cell loss and mossy fiber sprouting in the dentate gyrus
Santhakumar V.
Computational neuroscience in epilepsy, 2008, Pages: 89 - 111
ISBN: 9780123736499
Tags: morphology, connectivity, synapse probabilities
Vida I  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Morphology of Hippocampal Neurons
Vida I.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 27 - 68
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities

Supplemental PMIDs
Click here to view the list of PMIDs

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Bartos
    • HICAP-soma-outer-gcl (fits the general description of "DG HICAP" based on the distribution of axons and dendrites)
    • HICAP1 (Fig S4A)
    • HICAP2 (fits the general description of "DG HICAP" based on the distribution of axons and dendrites)
  • Lien
  • Turner

    • Morphology
    Soma
    DG:SG
    DG:H
    Axons
    DG:SMi
    Dendrites
    DG:SMo
    DG:SMi
    DG:SG
    DG:H

    Representative figure
    A high degree of spatial selectivity in the axonal and dendritic domains of physiologically identified local-circuit neurons in the dentate gyrus of the rat hippocampus.
    Han ZS, Buhl EH, Lorinczi Z, Somogyi P
    Eur J Neurosci, 1993 May 1, 5 (5), pages: 395 - 410
    PMID: 8261117; DOI: 10.1111/j.1460-9568.1993.tb00507.x


    FIG. 2. (A) Axonal and dendritic arborization of a hilar cell having an axonal field associated with the termination zone of the commissural and association pathways (HICAP cell {DG HICAP}) in the inner third of the molecular layer. The dendritic tree was reconstructed from the whole slice, but the axonal arborization (a, origin of axon) is shown here from one 60-[micro]m thick section for the sake of clarity. Most of the dendrites were only sparsely spiny, but one thick dendrite had a very densely spiny segment in the middle third of the molecular layer (arrows). (B) The position of the cell and its axonal arborization (shaded) is shown within the dentate gyrus. The response of this cell to a long depolarizing current pulse is shown in Figure 1. Scale bars: A, 100 [micro]m; B, 500 [micro]m.


    Molecular markers
    Positive
    CB1 (inference)
    CCK
    Negative
    AR-beta1 (multiple confirming inferences)
    CGRP (inference)
    CR (inference)
    GABAa\alpha 6 (inference)
    Gaba-a-alpha (inference)
    PV (multiple confirming inferences)
    vGluT2 (multiple confirming inferences)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Fast afterhyperpolaziring potential amplitude (Fast AHP): 18.6 mV (1); 2 sources (2): [11 , 18.6]
    Action potential amplitude (APampl): 50 mV (1); 1 source
    Action potential width (APwidth): 0.51 ms (1); 1 source
    Resting membrane potential (Vrest): -60.5±2.6 mV (7); 1 source
    Input resistance (Rin): 182.2±27.2 MΩ (7); 1 source
    Time constant (τm): 14.8±1.8 ms (7); 1 source
    Max firing rate (Max F.R.): 26.5±7.3 Hz (7); 1 source
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 0.1 mV (1); 1 source

    Notes
    Han et al., 1993: young adult female Wistar rats Mott et al., 1997: male 16-30 d-old Sprague Dawley rats After a thorough search, no data could be found for perisomatic contact with granule cells.

    Firing Pattern
    Images
    Image MissingImage MissingImage MissingImage Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]
    NASP [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=0.5;a= 0.039;b= -1.62;d= 49;C= 61;Vr= -61.28;Vt= -35.36;Vpeak= 38.79;Vmin= -60.77; Simulate
    subtype: 2 k=1.63;a= 0.012;b= 14.14;d= 0;C= 159;Vr= -60.81;Vt= -51.23;Vpeak= -11.68;Vmin= -60.66; Simulate
    Images
    Image MissingImage Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    DG Granule
    DG Mossy
    DG Basket
    DG HICAP
    DG MOPP

    Potential sources
    Excitatory or Inhibitory
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy MOLDEN
    DG AIPRIM
    DG Granulosum-targeting Axo-axonic*
    DG Basket GRALDEN*
    DG Basket CCK+
    DG Interneuron Specific COLTAR*
    DG COM-MOPP*
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG Interneuron Specific HIPRO*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 Perforant Path-Associated Projecting*
    CA3 Interneuron Specific Quad
    CA2 Pyramidal
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Back-Projection
    CA1 LMR Projecting
    CA1 Neurogliaform Projecting
    CA1 Perforant Path-Associated
    EC LI-II Pyramidal-Fan
    MEC LII Stellate
    EC LII-III Pyramidal-Tripolar
    EC LIV-V Pyramidal-Horizontal
    MEC LV Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    DG Axo-axonic
    DG Axo-axonic GRALDEN*

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    DG Granule
    DG Basket
    DG HICAP

    Potential targets
    Excitatory or Inhibitory
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Mossy MOLDEN
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Axo-axonic GRALDEN*
    DG Basket GRALDEN*
    DG Basket CCK+
    DG COM-MOPP*
    DG Interneuron Specific IMOT*
    DG Interneuron Specific HIMOLD*
    DG Interneuron Specific HIPRO*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG Total Molecular Layer
    DG Wide-Arbor Neurogliaform*

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value