DG Total Molecular Layer
* indicates new v2.0 neuron type
Name Supertype (ID:Family:Type:Subregion)
DG (i)3303 Total Molecular Layer S100601:Ivy/Neurogliaform Family:MOPP-like:DG

Name derivation
This is the simplest of the names in the cited literature.

Synonym(s)
DG interneuron with axons distributed diffusely throughout the molecular layer
DG TML cell
DG total molecular layer cell

List of articles
Click here to view the list
Bartos M  (2010) Hippocampal Microcircuits: A Computational Modeler's Resource Book
Fast and Slow GABAergic Transmission in Hippocampal Circuits
Bartos M, Sauer JF, Vida I, Kulik A.
Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, Pages: 129 - 162
ISBN: 9781441909954
Tags: morphology, connectivity, synapse probabilities
Mott DD  (1997) J Neurosci
Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity.
Mott DD, Turner DA, Okazaki MM, Lewis DV.
J Neurosci, 1997 Jun 1, 17 (11), Pages: 3990 - 4005
PMID: 9151716
Tags: morphology, membrane biophysics, firing patterns, synapse probabilities
Szabo GG  (2017) Cell Reports
Extended Interneuronal Network of the Dentate Gyrus
Szabo GG, Du X, Oijala M, Varga C, Parent JM, Soltesz I.
Cell Reports, 2017, 20 (6), Pages: 1262 - 1268
PMID: 28793251; DOI: 10.1016/j.celrep.2017.07.042
Tags: phases

List of Hippocampome.org to NeuroMorpho.Org mappings
Click here to view the list of mappings
  • Bartos
    • TML2 (fits the general description of "DG Total Molecular Layer" based on the distribution of axons and dendrites)
  • Lien
    • 171108-5 (Fig3a_Tri)
    • HIPP2_1 (fits the general description of "DG Total Molecular Layer" based on the distribution of axons and dendrites)
  • Vida

  • Morphology
    Soma
    DG:SG
    Axons
    DG:SMo
    DG:SMi
    DG:H
    Dendrites
    DG:SMo
    DG:SMi
    DG:H

    Representative figure
    Fast and Slow GABAergic Transmission in Hippocampal Circuits
    Bartos M, Sauer JF, Vida I, Kulik A
    Hippocampal Microcircuits: A Computational Modeler's Resource Book, 2010, pages: 129 - 162
    ISBN: 9781441909954;


    "Fig. 2 Slow inhibition among dendrite-targeting interneurons [in dentate gyrus]. A, Morphological reconstruction of a pair of synaptically connected dendrite inhibiting cells (DIs). Soma and dendrites of the presynaptic cell are depicted in green and the axon in red. Note that the axon distributes in the whole molecular layer, classifying this cell as total molecular layer cell (TML) {DG Total Molecular Layer}. The soma and dendrite of the postsynaptic interneuron are shown in black. The axon of this cell was not preserved during the recording. Arrowheads point to synaptic contacts which have been identified using electron microscopy (data not shown)."


    Molecular markers
    Positive
    None known
    Negative
    GABAa\alpha 6 (inference)
    mGluR1a (inference)
    SOM (multiple confirming inferences)
    Mixed expression
    None known

    Electrophysiological properties
    Key: [range] OR representative value±SD (measurements); Number of sources (total measurements): [min , max]

    Resting membrane potential (Vrest): -54.5±1.9 mV (13); 1 source
    Input resistance (Rin): 198.2±23.8 MΩ (13); 1 source
    Time constant (τm): 18.4±1.1 ms (13); 1 source
    Threshold potential (Vthresh): 15.2 mV (1); 1 source
    Fast afterhyperpolaziring potential amplitude (Fast AHP): 11 mV (1); 1 source
    Action potential amplitude (APampl): [43.2, 44.4] mV (2); 1 source
    Action potential width (APwidth): 0.86±0.11 ms (6); 1 source
    Max firing rate (Max F.R.): 50 Hz (1); 1 source
    Slow afterhyperpolarizing potential amplitude (Slow AHP): 4.5 mV (1); 1 source

    Notes
    Bartos (2010): A:SG is less than 15%.

    Firing Pattern
    Images
    Image MissingImage MissingImage MissingImage Missing
    Parameters View page
    ASP. [Evidence] [Firing Pattern]
    PSTUT [Evidence] [Firing Pattern]
    RASP.ASP. [Evidence] [Firing Pattern]
    RASP.NASP [Evidence] [Firing Pattern]

    Izhikevich Model
    Parameters Single Compartment Downloads Simulate
    subtype: 1 k=0.92;a= 0.001;b= -3.12;d= 8;C= 236;Vr= -54.91;Vt= -41.69;Vpeak= -11.61;Vmin= -48.73; Simulate
    subtype: 2 k=3.53;a= 0.001;b= 16.76;d= 2;C= 429;Vr= -54.05;Vt= -37.23;Vpeak= -10.76;Vmin= -47.14; Simulate
    subtype: 3 k=2.69;a= 0.002;b= -46.08;d= 77;C= 275;Vr= -54.61;Vt= -43.22;Vpeak= -11.34;Vmin= -46.83; Simulate
    subtype: 4 k=0.65;a= 0.008;b= -10.12;d= 196;C= 149;Vr= -54.94;Vt= -36.5;Vpeak= 33.75;Vmin= -30.49; Simulate
    subtype: 5 k=3.83;a= 0.01;b= -4.89;d= 57;C= 202;Vr= -54.2;Vt= -43.78;Vpeak= -11.06;Vmin= -47.1; Simulate
    Images
    Image MissingImage MissingImage MissingImage MissingImage Missing
    ModelDB Model
    Model Accession Number PubMed ID

    Sources of Input
    Known sources
    Excitatory or Inhibitory
    DG Total Molecular Layer

    Potential sources
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy
    DG Mossy MOLDEN
    DG AIPRIM
    DG Interneuron Specific COLTAR*
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG Interneuron Specific HIPRO*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA3c Pyramidal
    CA3c Umbrella Pyramidal*
    CA3 Spiny Lucidum
    CA3 Mossy Fiber-Associated
    CA3 Mossy Fiber-Associated ORDEN
    CA3 Perforant Path-Associated Projecting*
    CA3 Interneuron Specific Quad
    CA2 Pyramidal
    CA1 Local-Projecting Cajal-Retzius*
    CA1 Back-Projection
    CA1 LMR Projecting
    CA1 Neurogliaform Projecting
    CA1 Perforant Path-Associated
    EC LI-II Pyramidal-Fan
    MEC LII Stellate
    EC LII-III Pyramidal-Tripolar
    EC LIV-V Pyramidal-Horizontal
    MEC LV Pyramidal

    Potential sources known to be avoided
    Excitatory or Inhibitory
    DG Axo-axonic
    DG Axo-axonic GRALDEN*

    Targets of Output
    Known targets
    Excitatory or Inhibitory
    DG Total Molecular Layer

    Potential targets
    Excitatory or Inhibitory
    DG Granule
    DG Adult-Born Immature Granule*
    DG Hilar Ectopic Granule
    DG Semilunar Granule
    DG Cajal-Retzius*
    DG Local-Projecting Cajal-Retzius*
    DG Mossy
    DG Mossy MOLDEN
    DG AIPRIM
    DG Axo-axonic
    DG Granulosum-targeting Axo-axonic*
    DG Axo-axonic GRALDEN*
    DG Basket
    DG Basket GRALDEN*
    DG Basket CCK+
    DG Interneuron Specific COLTAR*
    DG COM-MOPP*
    DG HICAP
    DG Interneuron Specific IMOT*
    DG Hilus-Associated Interneuron*
    DG Interneuron Specific HIMOLD*
    DG HIPP
    DG Recurrent HIPP*
    DG HIPP-CAP*
    DG Recurrent HIPP-CAP*
    DG Interneuron Specific HIPRO*
    DG HIPROM
    DG Ivy*
    DG MOCAP
    DG MOLAX
    DG Molecular Layer*
    DG Outer Molecular Layer
    DG MOPP
    DG Neurogliaform
    DG Wide-Arbor Neurogliaform*
    CA3 Interneuron Specific Quad
    CA1 Neurogliaform Projecting

    Potential targets known to be avoided
    Excitatory or Inhibitory
    none known

    Oscillation Phase Locking
    Category
    Value
    SWR ratio:2.14
    SWR ratio range:[2.14, 2.14]
    SWR ratio measurements:1
    SWR ratio representative selection:   mice, adult, male,
    juxtacellular, freely moving
    Other:DS_ratio
    Other representative selection:   mice, adult, male,
    juxtacellular, freely moving